RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

Catherine M. Guzzo; Christopher E. Berndsen; Jianmei Zhu; Vibhor Gupta; Ajit Datta; Roger A. Greenberg; Cynthia Wolberger; Michael J. Matunis

doi:10.1126/scisignal.2003485

Research ArticleDNA damage

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

Catherine M. Guzzo¹,
Christopher E. Berndsen²,*,
Jianmei Zhu¹,
Vibhor Gupta³,
Ajit Datta²,†,
Roger A. Greenberg³,
Cynthia Wolberger², and
Michael J. Matunis¹,‡

¹Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
²Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

↵‡To whom correspondence should be addressed. E-mail: mmatunis{at}jhsph.edu

↵* Present address: Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
↵† Present address: Department of Biochemistry, Bose Institute, P-1/12 CIT Scheme VIIM, Kolkata 700054, India.

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Science Signaling 04 Dec 2012:
Vol. 5, Issue 253, pp. ra88
DOI: 10.1126/scisignal.2003485

Catherine M. Guzzo

1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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Christopher E. Berndsen

2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Jianmei Zhu

1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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Vibhor Gupta

3Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Ajit Datta

2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Roger A. Greenberg

3Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Cynthia Wolberger

2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Michael J. Matunis

1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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For correspondence: mmatunis@jhsph.edu

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