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vol. 5 no. 253 ra89
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History:
- Received May 29, 2012
- Accepted November 14, 2012
- .
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Copyright © 2012, American Association for the Advancement of Science
Research ArticleCell Biology
G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
- Hashem A. Dbouk1,*,
- Oscar Vadas2,*,
- Aliaksei Shymanets3,
- John E. Burke2,
- Rachel S. Salamon1,
- Bassem D. Khalil1,
- Mathew O. Barrett4,
- Gary L. Waldo4,
- Chinmay Surve5,
- Christine Hsueh6,
- Olga Perisic2,
- Christian Harteneck3,
- Peter R. Shepherd7,
- T. Kendall Harden4,
- Alan V. Smrcka5,
- Ronald Taussig8,
- Anne R. Bresnick6,
- Bernd Nürnberg3,
- Roger L. Williams2,†, and
- Jonathan M. Backer1,†
- 1Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 2MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
- 3Department of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research Eberhard-Karls-Universität Tübingen, Tübingen 72074, Germany.
- 4Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
- 5Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
- 6Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 7Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1142, New Zealand.
- 8Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- ↵†To whom correspondence should be addressed. E-mail: rlw{at}mrc-lmb.cam.ac.uk (R.L.W.); jonathan.backer{at}einstein.yu.edu (J.M.B.)
-
↵* These authors contributed equally to this work.
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Science Signaling 04 Dec 2012:
Vol. 5, Issue 253, pp. ra89
DOI: 10.1126/scisignal.2003264
Vol. 5, Issue 253, pp. ra89
DOI: 10.1126/scisignal.2003264
Hashem A. Dbouk
1Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Oscar Vadas
2MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Aliaksei Shymanets
3Department of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research Eberhard-Karls-Universität Tübingen, Tübingen 72074, Germany.
John E. Burke
2MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Rachel S. Salamon
1Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bassem D. Khalil
1Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Mathew O. Barrett
4Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Gary L. Waldo
4Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Chinmay Surve
5Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Christine Hsueh
6Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Olga Perisic
2MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Christian Harteneck
3Department of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research Eberhard-Karls-Universität Tübingen, Tübingen 72074, Germany.
Peter R. Shepherd
7Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1142, New Zealand.
T. Kendall Harden
4Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Alan V. Smrcka
5Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Ronald Taussig
8Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Anne R. Bresnick
6Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bernd Nürnberg
3Department of Pharmacology and Experimental Therapy, Institute for Pharmacology and Toxicology and Interfaculty Center of Pharmacogenomics and Pharma Research Eberhard-Karls-Universität Tübingen, Tübingen 72074, Germany.
Roger L. Williams
2MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Jonathan M. Backer
1Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
