Contents
Vol 5, Issue 255
Contents
Research Articles
- IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors
By inactivating the insulin-like growth factor receptor, IGFBP7 suppresses growth and promotes cell death.
- c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis
The antiapoptotic protein c-FLIP blocks multiple cell death pathways in mice.
- A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane
A previously unknown module that mediates membrane binding is identified in the scaffold KSR.
Review
- Extracellular Phosphorylation and Phosphorylated Proteins: Not Just Curiosities But Physiologically Important
Proteomic data indicate that the phosphorylation of extracellular proteins and extracellular protein domains is a widespread phenomenon.
Editors' Choice
- Gonad–Life-Span Coupling
A developmental timing program is redeployed to extend life span in the absence of a germ line.
- Replicating Virus in the Autophagosome
Rotavirus initiates, but blocks completion of, autophagy to replicate and assemble new viral particles.
- Disrupting the Endothelial Barrier
A noncanonical pathway involving the adaptor MyD88 may contribute to the disruption of endothelial barrier function associated with inflammation.
- Spots to Remember
A male sex pheromone rapidly stimulates learning of place preference that is remembered for about 2 weeks.
- Neurons Get the Neuroligin-1 Advantage
The more neuroligin-1 present, the more likely a synapse is to form.
