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Research ArticleCell Biology
IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors
- Valentina Evdokimova1,2,
- Cristina E. Tognon3,
- Tania Benatar1,
- Wenyi Yang1,
- Konstantin Krutikov1,
- Michael Pollak4,
- Poul H. B. Sorensen3,5, and
- Arun Seth1,*
- 1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
- 2Institute of Protein Research, Pushchino, Moscow Region 142290, Russian Federation.
- 3Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
- 4Departments of Medicine and Oncology, McGill University and Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
- 5Department of Pathology, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
- ↵*To whom correspondence should be addressed. E-mail: arun.seth{at}utoronto.ca
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Science Signaling 18 Dec 2012:
Vol. 5, Issue 255, pp. ra92
DOI: 10.1126/scisignal.2003184
Vol. 5, Issue 255, pp. ra92
DOI: 10.1126/scisignal.2003184
Valentina Evdokimova
1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
2Institute of Protein Research, Pushchino, Moscow Region 142290, Russian Federation.
Cristina E. Tognon
3Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
Tania Benatar
1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
Wenyi Yang
1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
Konstantin Krutikov
1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
Michael Pollak
4Departments of Medicine and Oncology, McGill University and Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
Poul H. B. Sorensen
3Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
5Department of Pathology, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Arun Seth
1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
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