IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

Valentina Evdokimova; Cristina E. Tognon; Tania Benatar; Wenyi Yang; Konstantin Krutikov; Michael Pollak; Poul H. B. Sorensen; Arun Seth

doi:10.1126/scisignal.2003184

Research ArticleCell Biology

IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

Valentina Evdokimova¹,²,
Cristina E. Tognon³,
Tania Benatar¹,
Wenyi Yang¹,
Konstantin Krutikov¹,
Michael Pollak⁴,
Poul H. B. Sorensen³,⁵, and
Arun Seth¹,*

¹Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
²Institute of Protein Research, Pushchino, Moscow Region 142290, Russian Federation.
³Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
⁴Departments of Medicine and Oncology, McGill University and Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
⁵Department of Pathology, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

↵*To whom correspondence should be addressed. E-mail: arun.seth{at}utoronto.ca

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Science Signaling 18 Dec 2012:
Vol. 5, Issue 255, pp. ra92
DOI: 10.1126/scisignal.2003184

Valentina Evdokimova

1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

2Institute of Protein Research, Pushchino, Moscow Region 142290, Russian Federation.

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Cristina E. Tognon

3Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.

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Tania Benatar

1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

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Wenyi Yang

1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

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Konstantin Krutikov

1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

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Michael Pollak

4Departments of Medicine and Oncology, McGill University and Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

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Poul H. B. Sorensen

3Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.

5Department of Pathology, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

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Arun Seth

1Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

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For correspondence: arun.seth@utoronto.ca

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IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

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