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vol. 5 no. 255 ra93
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- Received August 30, 2012
- Accepted November 30, 2012
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Copyright © 2012, American Association for the Advancement of Science
Research ArticleCell Biology
c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis
- Xuehua Piao1,2,
- Sachiko Komazawa-Sakon1,
- Takashi Nishina1,2,
- Masato Koike3,
- Jiang-Hu Piao1,4,
- Hanno Ehlken5,
- Hidetake Kurihara6,
- Mutsuko Hara2,
- Nico Van Rooijen7,
- Günther Schütz8,
- Masaki Ohmuraya9,
- Yasuo Uchiyama3,
- Hideo Yagita1,
- Ko Okumura1,2,
- You-Wen He10, and
- Hiroyasu Nakano1,11,*
- 1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
- 2Atopy Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
- 3Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
- 4Department of Immunology, School of Basic Medical Science, Ningxia Medical College, 1160 Shengli Street, Xingqing-Qu, Yinchuan 750004, China.
- 5University Medical Center Hamburg-Eppendorf, I. Department of Internal Medicine, Martin Str. 52, Hamburg 20246, Germany.
- 6Department of Anatomy, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
- 7Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam 1081 BT, Netherlands.
- 8Department of Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
- 9Center for Animal Resources and Development, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
- 10Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
- 11Laboratory of Molecular and Biochemical Research, Biomedical Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
- ↵*To whom correspondence should be addressed. E-mail: hnakano{at}juntendo.ac.jp
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Science Signaling 18 Dec 2012:
Vol. 5, Issue 255, pp. ra93
DOI: 10.1126/scisignal.2003558
Vol. 5, Issue 255, pp. ra93
DOI: 10.1126/scisignal.2003558
Xuehua Piao
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
2Atopy Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Sachiko Komazawa-Sakon
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Takashi Nishina
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
2Atopy Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Masato Koike
3Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Jiang-Hu Piao
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
4Department of Immunology, School of Basic Medical Science, Ningxia Medical College, 1160 Shengli Street, Xingqing-Qu, Yinchuan 750004, China.
Hanno Ehlken
5University Medical Center Hamburg-Eppendorf, I. Department of Internal Medicine, Martin Str. 52, Hamburg 20246, Germany.
Hidetake Kurihara
6Department of Anatomy, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Mutsuko Hara
2Atopy Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Nico Van Rooijen
7Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam 1081 BT, Netherlands.
Günther Schütz
8Department of Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Masaki Ohmuraya
9Center for Animal Resources and Development, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Yasuo Uchiyama
3Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Hideo Yagita
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Ko Okumura
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
2Atopy Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
You-Wen He
10Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Hiroyasu Nakano
1Department of Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
11Laboratory of Molecular and Biochemical Research, Biomedical Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
