Contents
Vol 6, Issue 256
Contents
Editorial Guide
- 2012: Signaling Breakthroughs of the Year
Synthetic biology, cancer signaling, and metabolism all made the list of breakthroughs in basic signal transduction research or the translational application of signaling knowledge.
Research Article
- Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases
The extent of receptor clustering determines which kinases mediate B cell receptor signaling.
Research Resource
- Nitric Oxide Regulates Mitochondrial Fatty Acid Metabolism Through Reversible Protein S-Nitrosylation
S-nitrosylation increases the catalytic efficiency of an enzyme critical to fatty acid β-oxidation.
Podcast
- Science Signaling Podcast: 1 January 2013
B cell receptor clustering determines which kinases are required for signaling.
Editors' Choice
- One Gene, Two Paths to Muscle Fitness
Muscle mass and endurance are regulated independently by two proteins encoded by the same gene.
- Chronic Infection, But Limited Inflammation
NO-mediated modification of the inflammasome limits tissue damage in chronic infection.
- Granule Calcium for Cell Killing
NAADP promotes exocytosis of cytolytic granules by stimulating calcium release from the granules.
- Inhibit Autophagy, STAT!
Cytoplasmic STAT3 suppresses autophagy under basal conditions through a nontranscriptional mechanism.