Contents

Contents

• Editorial Guide

  • 2012: Signaling Breakthroughs of the Year

    By Michael B. Yaffe, Nancy R. Gough

    Science Signaling01 Jan 2013 : eg1 Full AccessRestricted Access

    Synthetic biology, cancer signaling, and metabolism all made the list of breakthroughs in basic signal transduction research or the translational application of signaling knowledge.

    • Abstract
    • Full Text
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• Research Article

  • Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases

    By Sayak Mukherjee, Jing Zhu, Julie Zikherman, Ramya Parameswaran, Theresa A. Kadlecek, Qi Wang, Byron Au-Yeung, Hidde Ploegh, John Kuriyan, Jayajit Das, Arthur Weiss

    Science Signaling01 Jan 2013 : ra1 Full AccessRestricted Access

    The extent of receptor clustering determines which kinases mediate B cell receptor signaling.

    • Editor's Summary
    • Abstract
    • Full Text
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• Research Resource

  • Nitric Oxide Regulates Mitochondrial Fatty Acid Metabolism Through Reversible Protein S-Nitrosylation

    By Paschalis-Thomas Doulias, Margarita Tenopoulou, Jennifer L. Greene, Karthik Raju, Harry Ischiropoulos

    Science Signaling01 Jan 2013 : rs1 Full AccessRestricted Access

    S-nitrosylation increases the catalytic efficiency of an enzyme critical to fatty acid β-oxidation.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 1 January 2013

    By Arthur Weiss, Jayajit Das, Annalisa M. VanHook

    Science Signaling01 Jan 2013 : pc1 Full AccessRestricted Access

    B cell receptor clustering determines which kinases are required for signaling.

    • Abstract
    • Full Text

• Editors' Choice

  • One Gene, Two Paths to Muscle Fitness

    By Leslie K. Ferrarelli

    Science Signaling01 Jan 2013 : ec1 Full AccessRestricted Access

    Muscle mass and endurance are regulated independently by two proteins encoded by the same gene.

    • Abstract

  • Chronic Infection, But Limited Inflammation

    By Nancy R. Gough

    Science Signaling01 Jan 2013 : ec2 Full AccessRestricted Access

    NO-mediated modification of the inflammasome limits tissue damage in chronic infection.

    • Abstract

  • Granule Calcium for Cell Killing

    By Annalisa M. VanHook

    Science Signaling01 Jan 2013 : ec3 Full AccessRestricted Access

    NAADP promotes exocytosis of cytolytic granules by stimulating calcium release from the granules.

    • Abstract

  • Inhibit Autophagy, STAT!

    By Wei Wong

    Science Signaling01 Jan 2013 : ec4 Full AccessRestricted Access

    Cytoplasmic STAT3 suppresses autophagy under basal conditions through a nontranscriptional mechanism.

    • Abstract