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vol. 6 no. 256 ra1
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- Received May 11, 2012
- Accepted December 13, 2012
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Copyright © 2013, American Association for the Advancement of Science
Research ArticleImmunology
Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases
- Sayak Mukherjee1,
- Jing Zhu2,
- Julie Zikherman2,
- Ramya Parameswaran2,
- Theresa A. Kadlecek2,
- Qi Wang3,
- Byron Au-Yeung2,
- Hidde Ploegh4,
- John Kuriyan3,
- Jayajit Das1,5,6,*, and
- Arthur Weiss2,*
- 1Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA.
- 2The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
- 3Department of Molecular and Cell Biology, Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
- 4Department of Biology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 5Department of Physics, The Ohio State University, Columbus, OH 43210, USA.
- 6Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
- ↵*To whom correspondence should be addressed. E-mail: aweiss{at}medicine.ucsf.edu (A.W.); das.70{at}osu.edu (J.D.)
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Science Signaling 01 Jan 2013:
Vol. 6, Issue 256, pp. ra1
DOI: 10.1126/scisignal.2003220
Vol. 6, Issue 256, pp. ra1
DOI: 10.1126/scisignal.2003220
Sayak Mukherjee
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA.
Jing Zhu
The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Julie Zikherman
The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Ramya Parameswaran
The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Theresa A. Kadlecek
The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Qi Wang
Department of Molecular and Cell Biology, Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Byron Au-Yeung
The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Hidde Ploegh
Department of Biology, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
John Kuriyan
Department of Molecular and Cell Biology, Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Jayajit Das
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA.Department of Physics, The Ohio State University, Columbus, OH 43210, USA.Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
Arthur Weiss
The Rosalind Russell Research Center for Arthritis, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
