Contents

Contents

• Research Articles

  • BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

    By Yixin Yao, Milind Suraokar, Bryant G. Darnay, Brett G. Hollier, Tattym E. Shaiken, Takayuki Asano, Chien-Hung Chen, Benny H.-J. Chang, Yiling Lu, Gordon B. Mills, Dos Sarbassov, Sendurai A. Mani, James L. Abbruzzese, Shrikanth A. G. Reddy

    Science Signaling08 Jan 2013 : ra2 Full AccessRestricted Access

    Activation of Akt1 during adipocyte differentiation requires a binding partner called BSTA.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor–Mediated Activation of Akt Signaling

    By Wei-Lei Yang, Guoxiang Jin, Chien-Feng Li, Yun Seong Jeong, Asad Moten, Dazhi Xu, Zizhen Feng, Wei Chen, Zhen Cai, Bryant Darnay, Wei Gu, Hui-Kuan Lin

    Science Signaling08 Jan 2013 : ra3 Full AccessRestricted Access

    The deubiquitinase CYLD suppresses activation of the tumor growth–promoting kinase Akt.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • The Akt DUBbed InAktive

    By Kui Lin

    Science Signaling08 Jan 2013 : pe1 Full AccessRestricted Access

    Deubiquitination limits the kinase activity of Akt in the absence of growth factor stimulation.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Protease-Independent Invasion

    By Annalisa M. VanHook

    Science Signaling08 Jan 2013 : ec5 Full AccessRestricted Access

    Independently of its protease activity, a metalloproteinase cooperates with an integrin to promote mammary epithelial tube branching.

    • Abstract

  • Inhibiting Hippo

    By John F. Foley

    Science Signaling08 Jan 2013 : ec6 Full AccessRestricted Access

    Orthologs of the mammalian nutrient sensor AMPK inhibit Hippo signaling in Drosophila.

    • Abstract

  • Regulation in Reserve

    By Leslie K. Ferrarelli

    Science Signaling08 Jan 2013 : ec7 Full AccessRestricted Access

    Sequestered microRNAs serve as a regulatory reserve pool to enable quiescent cells to effectively respond to mitogenic signals.

    • Abstract

  • Released by Calcium

    By Wei Wong

    Science Signaling08 Jan 2013 : ec8 Full AccessRestricted Access

    Ca²⁺ promotes the tyrosine phosphorylation of CD3 in stimulated T cells by displacing it from the plasma membrane.

    • Abstract

  • Converging on Syx

    By Nancy R. Gough

    Science Signaling08 Jan 2013 : ec9 Full AccessRestricted Access

    Two opposing signals controlling endothelial cell permeability converge on the Rho guanine nucleotide exchange factor Syx.

    • Abstract