Contents
Vol 6, Issue 257
Contents
Research Articles
- BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation
Activation of Akt1 during adipocyte differentiation requires a binding partner called BSTA.
- Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor–Mediated Activation of Akt Signaling
The deubiquitinase CYLD suppresses activation of the tumor growth–promoting kinase Akt.
Perspective
- The Akt DUBbed InAktive
Deubiquitination limits the kinase activity of Akt in the absence of growth factor stimulation.
Editors' Choice
- Protease-Independent Invasion
Independently of its protease activity, a metalloproteinase cooperates with an integrin to promote mammary epithelial tube branching.
- Inhibiting Hippo
Orthologs of the mammalian nutrient sensor AMPK inhibit Hippo signaling in Drosophila.
- Regulation in Reserve
Sequestered microRNAs serve as a regulatory reserve pool to enable quiescent cells to effectively respond to mitogenic signals.
- Released by Calcium
Ca2+ promotes the tyrosine phosphorylation of CD3 in stimulated T cells by displacing it from the plasma membrane.
- Converging on Syx
Two opposing signals controlling endothelial cell permeability converge on the Rho guanine nucleotide exchange factor Syx.
