Contents
Vol 6, Issue 258
Contents
Editorial Guide
- Focus Issue: Understanding Mechanisms of Inflammation
Inflammatory responses can be both beneficial and detrimental.
Research Resources
- Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation
Quantitative proteomic analysis of inflamed mouse skin reveals mediators of the inflammatory response in vivo.
- A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-κB Signaling Pathways
A small interfering RNA screen provides insight into the mechanisms of Crohn’s disease pathogenesis.
Perspectives
- The FLIP Side of Life
The protein c-FLIP plays a role in preventing cell death by both apoptosis and necroptosis.
- Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases
Four cytokines play complex roles in neuroinflammatory diseases.
Podcast
- Science Signaling Podcast: 15 January 2013
Identification of inflammatory response regulators sheds light on disease.
Editors' Choice
- Preventing Airway Hypercontractility
Mice deficient in the ligand Mfge8, an integrin-binding protein, have enhanced contractility of airway smooth muscle cells.
- Macrophage JNK in Metabolic Disease
A kinase in macrophages is required for high-fat diet–induced metabolic changes and inflammation.
- Chemotherapeutics Inflame Tumor Growth
The mechanism that induces an antitumor immune response from 5-fluorouracil and gemcitabine also initiates protumorigenic inflammation.
- From Indolent to Metastatic
A transcription factor promotes the metastasis of nonaggressive PTEN-null prostate tumors through a nontranscriptional mechanism.
- Tapping Lines of Communication
Carnivorous fungi identify prey by intercepting pheromone communication.
- Fungal Wanderlust
Yeast use a wandering polarity patch to track chemical gradients and identify appropriate mating partners.
- Stress Protector
Ketone bodies, metabolites that accumulate during fasting, change gene expression by inhibiting histone deacetylases.
- The Adult Astrocyte Is Different
The expression of metabotropic glutamate receptors in brain astrocytes is down-regulated in early postnatal development.
- Activation and Inactivation of Caspase-8 by Ubiquitylation
Whereas Cullin3-mediated ubiquitylation of caspase-8 promotes its activation, ubiquitylation by TRAF2 promotes its degradation.
