Contents

Contents

• Research Articles

  • Phosphoinositide 3-Kinase γ Inhibits Cardiac GSK-3 Independently of Akt

    By Maradumane L. Mohan, Babal K. Jha, Manveen K. Gupta, Neelakantan T. Vasudevan, Elizabeth E. Martelli, John David Mosinski, Sathyamangla V. Naga Prasad

    Science Signaling22 Jan 2013 : ra4 Full AccessRestricted Access

    A kinase promotes cardiac hypertrophy through a kinase-independent mechanism.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

    By Jordi Carreras Puigvert, Louise von Stechow, Ramakrishnaiah Siddappa, Alex Pines, Mahnoush Bahjat, Lizette C. J. M. Haazen, Jesper V. Olsen, Harry Vrieling, John H. N. Meerman, Leon H. F. Mullenders, Bob van de Water, Erik H. J. Danen

    Science Signaling22 Jan 2013 : ra5 Full AccessRestricted Access

    Genotoxic stress induces Wnt signaling that attenuates apoptosis in embryonic stem cells.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • The Hippo Size Control Pathway—Ever Expanding

    By Jane I. Lin, Carole L. C. Poon, Kieran F. Harvey

    Science Signaling22 Jan 2013 : pe4 Full AccessRestricted Access

    More signals controlling the nuclear localization of YAP are identified.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Signaling Differentiation

    By L. Bryan Ray

    Science Signaling22 Jan 2013 : ec19 Full AccessRestricted Access

    A molecular mechanism to inhibit Delta-Notch signaling and initiate neurogenesis is elucidated.

    • Abstract

  • Sonic Hedgehog Mediates Pathogen-Specific Response

    By Annalisa M. VanHook

    Science Signaling22 Jan 2013 : ec20 Full AccessRestricted Access

    Sonic hedgehog signaling modulates the immune response to Mycobacterium bovis.

    • Abstract

  • Controlling the Allergic Reaction

    By Leslie K. Ferrarelli

    Science Signaling22 Jan 2013 : ec21 Full AccessRestricted Access

    The alarmins Mrp8 and Mrp14 function as both activators and inhibitors of the immune response.

    • Abstract

  • Nitrosylation Promotes AMPA Receptor Phosphorylation

    By Nancy R. Gough

    Science Signaling22 Jan 2013 : ec22 Full AccessRestricted Access

    S-Nitrosylation of an AMPA receptor subunit contributes to activity-dependent regulation in channel activity.

    • Abstract

  • Defeat, Distress, and Glucocorticoids

    By Peter R. Stern

    Science Signaling22 Jan 2013 : ec23 Full AccessRestricted Access

    Social stress can act through glucocorticoids on discrete dopamine-controlled neuronal pathways in the rodent brain to influence behavior.

    • Abstract

  • A Well-Defined Path

    By Kristen L. Mueller

    Science Signaling22 Jan 2013 : ec24 Full AccessRestricted Access

    In mouse skin, immune cells migrate toward lymphatic vessels along an immobilized chemokine gradient.

    • Abstract