Contents
Vol 6, Issue 261
Contents
Research Articles
- Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development
Skin development requires reactive oxygen species generated by mitochondria in keratinocytes.
- Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy
A crystal structure of an autophagy receptor with a ligand reveals how Salmonella is specifically targeted for degradation.
Perspective
- Therapeutic Hints from Analyzing the Attractor Landscape of the p53 Regulatory Circuit
Analysis of network dynamics holds promise for development of novel therapies.
Podcast
- Science Signaling Podcast: 5 February 2013
An autophagy receptor specifically targets Salmonella for degradation in infected cells.
Editors' Choice
- Separating Fat Functions
The Hippo and PCP signaling activities of the atypical cadherin Fat rely on different regions of the Fat intracellular domain.
- Surviving Birth
Knock-in mice reveal a critical role for mTORC1 in stimulating autophagy to survive the hypoglycemic period that follows birth.
- The Tribble Threat in Breast Cancer
The pseudokinase TRB3 stimulates pathways promoting Notch-induced breast cancer progression and metastasis.
- Modifying Deubiquitinases
A technique for developing specific and potent enzyme inhibitors is validated on enzymes of the ubiquitin‑proteasome system.
- Identifying the Goldilocks Model
Computational methods can be used to identify models that are neither too simple nor too complex to be accurate.
