12 February 2013
Vol 6, Issue 262
  • Contents

    • Research Articles

    • Perspective

    • Podcast

      • Science Signaling Podcast: 12 February 2013

        In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions.

    • Editors' Choice

      • A Tail of ROS

        Reactive oxygen species produced by NADPH oxidase complex initiates Wnt-mediated regeneration in tadpoles.

      • Yorkie’s Mask

        Mask acts as a cofactor for transcriptional coactivators in the Hippo pathway to modulate gene transcription.

      • Protecting the Brain

        Astrocytes suppress neuroinflammation through activation of their dopamine D2 receptors.

      • E. coli kNOws How to Win

        During inflammation, Escherichia coli uses nitrate respiration to gain a growth advantage over other gut bacteria.

      • A Sugary Path to the Nucleus

        High glucose concentrations stimulate Wnt signaling by promoting the nuclear accumulation of β-catenin.

      • Fixing Broken DNA

        In mammalian cells, Rap1-interacting factor 1 protects DNA ends against resection.

      • Parainfluenza 5 and MDA5

        The crystal structure of a viral protein core complex reveals how paramyxoviruses inhibit the innate immune response.

      • Sweet Enough to Flower

        Specific sugar signals integrate carbohydrate status with day length and developmental age to regulate flowering.

About The Cover

Cover image expansion

Online Cover This week features a Research Article (also listen to the accompanying Podcast) describing how HIF-1α inhibits a helicase complex that unwinds DNA in preparation for replication through a nontranscriptional mechanism, thereby inducing cell cycle arrest during hypoxia. The image is an artist's depiction of replicating DNA. [Image: Yana Hammond/Science Signaling]