Contents
Vol 6, Issue 262
Contents
Research Articles
- A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
In response to hypoxia, HIF-1α induces cell cycle arrest by inhibiting a helicase complex that unwinds DNA in preparation for replication.
- ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser777 Inhibits Signaling
Serine phosphorylation limits signaling by a fibroblast growth factor receptor.
Perspective
- Of Proneurotrophins and Their Antineurotrophic Effects
The precursor forms of neurotrophins are functional and mediate opposite signals from the mature forms.
Podcast
- Science Signaling Podcast: 12 February 2013
In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions.
Editors' Choice
- A Tail of ROS
Reactive oxygen species produced by NADPH oxidase complex initiates Wnt-mediated regeneration in tadpoles.
- Yorkie’s Mask
Mask acts as a cofactor for transcriptional coactivators in the Hippo pathway to modulate gene transcription.
- Protecting the Brain
Astrocytes suppress neuroinflammation through activation of their dopamine D2 receptors.
- E. coli kNOws How to Win
During inflammation, Escherichia coli uses nitrate respiration to gain a growth advantage over other gut bacteria.
- A Sugary Path to the Nucleus
High glucose concentrations stimulate Wnt signaling by promoting the nuclear accumulation of β-catenin.
- Fixing Broken DNA
In mammalian cells, Rap1-interacting factor 1 protects DNA ends against resection.
- Parainfluenza 5 and MDA5
The crystal structure of a viral protein core complex reveals how paramyxoviruses inhibit the innate immune response.
- Sweet Enough to Flower
Specific sugar signals integrate carbohydrate status with day length and developmental age to regulate flowering.
