Contents

Contents

• Research Resources

  • A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

    By Sehyun Chae, Byung Yong Ahn, Kyunghee Byun, Young Min Cho, Myeong-Hee Yu, Bonghee Lee, Daehee Hwang, Kyong Soo Park

    Science Signaling26 Feb 2013 : rs4 Full AccessRestricted Access

    Transcriptional profiling and transcription factor matching reveal potential targets for therapies against diseases associated with mitochondrial dysfunction.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Protein Complex–Based Analysis Framework for High-Throughput Data Sets

    By Arunachalam Vinayagam, Yanhui Hu, Meghana Kulkarni, Charles Roesel, Richelle Sopko, Stephanie E. Mohr, Norbert Perrimon

    Science Signaling26 Feb 2013 : rs5 Full AccessRestricted Access

    An analysis tool maps network dynamics at the protein complex level in multiple species.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Review

  • Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis

    By Philip D. King, Beth A. Lubeck, Philip E. Lapinski

    Science Signaling26 Feb 2013 : re1 Full AccessRestricted Access

    Mutations in Ras guanosine triphophatase–activating proteins (RasGAPs) cause disease in humans.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Longevity Through Cold Transcription

    By Leslie K. Ferrarelli

    Science Signaling26 Feb 2013 : ec49 Full AccessRestricted Access

    At cold temperatures, the cation channel TRPA1 extends life span in worms.

    • Abstract

  • Delivering STAT3 into Mitochondria

    By Annalisa M. VanHook

    Science Signaling26 Feb 2013 : ec50 Full AccessRestricted Access

    A component of the electron transport chain complex I escorts STAT3 into mitochondria.

    • Abstract

  • Targeting Dimerization

    By Nancy R. Gough

    Science Signaling26 Feb 2013 : ec51 Full AccessRestricted Access

    Targeting the dimerization interface of Raf disrupts signaling by all but the most active mutants.

    • Abstract

  • Caspase-11–Dependent Pyroptosis

    By Kristen L. Mueller

    Science Signaling26 Feb 2013 : ec52 Full AccessRestricted Access

    Caspase-11 triggers cell death in response to bacteria that gain access to the cytosol of macrophages.

    • Abstract

  • Keeping Antibody Production Going

    By John F. Foley

    Science Signaling26 Feb 2013 : ec53 Full AccessRestricted Access

    Autophagy is required for the maintenance of antibody production by plasma cells.

    • Abstract