Contents
Vol 6, Issue 264
Contents
Research Resources
- A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways
Transcriptional profiling and transcription factor matching reveal potential targets for therapies against diseases associated with mitochondrial dysfunction.
- Protein Complex–Based Analysis Framework for High-Throughput Data Sets
An analysis tool maps network dynamics at the protein complex level in multiple species.
Review
- Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis
Mutations in Ras guanosine triphophatase–activating proteins (RasGAPs) cause disease in humans.
Editors' Choice
- Longevity Through Cold Transcription
At cold temperatures, the cation channel TRPA1 extends life span in worms.
- Delivering STAT3 into Mitochondria
A component of the electron transport chain complex I escorts STAT3 into mitochondria.
- Targeting Dimerization
Targeting the dimerization interface of Raf disrupts signaling by all but the most active mutants.
- Caspase-11–Dependent Pyroptosis
Caspase-11 triggers cell death in response to bacteria that gain access to the cytosol of macrophages.
- Keeping Antibody Production Going
Autophagy is required for the maintenance of antibody production by plasma cells.
