Research ResourceCell Biology

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

See allHide authors and affiliations

Science Signaling  26 Feb 2013:
Vol. 6, Issue 264, pp. rs4
DOI: 10.1126/scisignal.2003266

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests
CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

  • An Alternative Approach for Decoding Mitochondrial Retrograde Signaling

    In the interesting and comprehensive study by Chae et al., the authors engineered cells to have quantitative variation in the amount of mitochondrial DNA by using a mutation (mt3243) that reduced the expression of proteins controlling oxidative phosphorylation and mitochondrial function and induced mitochondrial retrograde signaling pathways. In our study, which was published two years ago, we used a similar, but distinct, approach for investigation of mitoc...

    Show More
    Competing Interests: None declared.
  • Mitochondrial Retrograde Signaling Pathways

    We would like to congratulate Kyong Soo Park and colleagues for their study on decoding mitochondrial retrograde signaling pathways. The authors used cells with an A3243G mutation (mt3243) in the leucine transfer RNA (tRNALeu) to explore mitochondrial retrograde signaling pathways. We would like to ask Kyong Soo Park and colleagues whether mutations in any other mtDNA locus would activate the same retrograde sig...

    Show More
    Competing Interests: None declared.