Research ResourceCell Biology

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

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Science Signaling  26 Feb 2013:
Vol. 6, Issue 264, pp. rs4
DOI: 10.1126/scisignal.2003266

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  • An Alternative Approach for Decoding Mitochondrial Retrograde Signaling

    In the interesting and comprehensive study by Chae et al., the authors engineered cells to have quantitative variation in the amount of mitochondrial DNA by using a mutation (mt3243) that reduced the expression of proteins controlling oxidative phosphorylation and mitochondrial function and induced mitochondrial retrograde signaling pathways. In our study, which was published two years ago, we used a similar, but distinct, approach for investigation of mitoc...

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    Competing Interests: None declared.
  • Mitochondrial Retrograde Signaling Pathways

    We would like to congratulate Kyong Soo Park and colleagues for their study on decoding mitochondrial retrograde signaling pathways. The authors used cells with an A3243G mutation (mt3243) in the leucine transfer RNA (tRNALeu) to explore mitochondrial retrograde signaling pathways. We would like to ask Kyong Soo Park and colleagues whether mutations in any other mtDNA locus would activate the same retrograde sig...

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    Competing Interests: None declared.

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