Contents
Vol 6, Issue 265
Contents
Research Articles
- The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis
WNT5A activates ARF6 to liberate β-catenin from adherens junctions, thereby increasing the amount that can mediate gene transcription.
- Akt and PP2A Reciprocally Regulate the Guanine Nucleotide Exchange Factor Dock6 to Control Axon Growth of Sensory Neurons
The phosphorylation status of Dock6 causes sensory neuron axons to switch from extension to branching.
Editors' Choice
- Swapping Mood Disorders for Diabetes
Serotonin-targeted antidepressants may induce diabetes by disrupting the insulin signaling pathway and inducing cell death in pancreatic β cells.
- Atypical GLI Activation
An atypical protein kinase C promotes growth of basal cell carcinoma cells by stimulating activation of the transcription factor GLI1.
- Unable to Filter the Signal
The Fragile X mental retardation protein interacts with a specific type of potassium channel to enhance the channel’s calcium sensitivity and limit action potential firing.
- A Role for IFN-ε
The cytokine interferon-ε is expressed in the female reproductive tract and protects against sexually transmitted diseases.
- Mighty Male Microbes
In mice, the gut microbiota influences levels of sex hormones and the development of autoimmune disease.
- Mastering Meiosis
Two kinases mediate a partner-changing interlude that prevents chromosome segregation errors in yeast meiosis.
- Genetic Clues to Meningioma
The mutational profiles of meningiomas, a common type of brain tumor, correlate with their anatomical location and clinical status.
