05 March 2013
Vol 6, Issue 265
  • Contents

    • Research Articles

    • Editors' Choice

      • Swapping Mood Disorders for Diabetes

        Serotonin-targeted antidepressants may induce diabetes by disrupting the insulin signaling pathway and inducing cell death in pancreatic β cells.

      • Atypical GLI Activation

        An atypical protein kinase C promotes growth of basal cell carcinoma cells by stimulating activation of the transcription factor GLI1.

      • Unable to Filter the Signal

        The Fragile X mental retardation protein interacts with a specific type of potassium channel to enhance the channel’s calcium sensitivity and limit action potential firing.

      • A Role for IFN-ε

        The cytokine interferon-ε is expressed in the female reproductive tract and protects against sexually transmitted diseases.

      • Mighty Male Microbes

        In mice, the gut microbiota influences levels of sex hormones and the development of autoimmune disease.

      • Mastering Meiosis

        Two kinases mediate a partner-changing interlude that prevents chromosome segregation errors in yeast meiosis.

      • Genetic Clues to Meningioma

        The mutational profiles of meningiomas, a common type of brain tumor, correlate with their anatomical location and clinical status.

About The Cover

Cover image expansion

Online Cover This week features a Research Article describing how the phosphorylation status of the guanine nucleotide exchange factor Dock6 determines whether it promotes axon extension or branching in sensory neurons. Mice lacking Dock6 showed impaired axonal extension after injury to the sciatic nerve. The image shows an artist's depiction of a peripheral nerve injury. [Image: Chris Bickel/AAAS]