Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

Sungguan Hong; Hyangsoon Noh; Haoming Chen; Ravi Padia; Zhixing K. Pan; Shi-Bing Su; Qing Jing; Han-Fei Ding; Shuang Huang

doi:10.1126/scisignal.2003706

Research ArticleMICRORNAs

Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

Sungguan Hong¹,*,
Hyangsoon Noh¹,*,
Haoming Chen²,
Ravi Padia¹,
Zhixing K. Pan³,
Shi-Bing Su⁴,
Qing Jing⁵,
Han-Fei Ding⁶,⁷, and
Shuang Huang¹,⁴,⁷,†

¹Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.
²State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, College of Life Science, Fudan University, Shanghai 200433, China.
³Department of Immunology and Medical Microbiology, University of Toledo Health Science Center, Toledo, OH 43606, USA.
⁴Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
⁵Changhai Hospital, Shanghai 200433, China.
⁶Department of Pathology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.
⁷Cancer Center, Georgia Health Sciences University, Augusta, GA 30912, USA.

↵†Corresponding author. E-mail: shuang{at}gru.edu

↵* These authors contributed equally to this work.

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Science Signaling 12 Mar 2013:
Vol. 6, Issue 266, pp. ra16
DOI: 10.1126/scisignal.2003706

Sungguan Hong

1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.

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Hyangsoon Noh

1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.

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Haoming Chen

2State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, College of Life Science, Fudan University, Shanghai 200433, China.

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Ravi Padia

1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.

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Zhixing K. Pan

3Department of Immunology and Medical Microbiology, University of Toledo Health Science Center, Toledo, OH 43606, USA.

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Shi-Bing Su

4Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

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Qing Jing

5Changhai Hospital, Shanghai 200433, China.

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Han-Fei Ding

6Department of Pathology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.

7Cancer Center, Georgia Health Sciences University, Augusta, GA 30912, USA.

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Shuang Huang

1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.

4Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

7Cancer Center, Georgia Health Sciences University, Augusta, GA 30912, USA.

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For correspondence: shuang@gru.edu

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Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

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