Contents
Vol 6, Issue 268
Contents
Editorial Guide
- Focus Issue: From Genomic Mutations to Oncogenic Pathways
Understanding alterations in signaling networks is key to developing rational, personalized cancer therapies.
Research Articles
- PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis
Combining drugs that inhibit antiapoptotic proteins with oncogenic kinase inhibitors may overcome drug resistance in cancer therapy.
- Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis
Understanding the signaling mechanisms that can lead to T cell leukemia may enable personalized therapies.
Research Resource
- Kinase-Substrate Enrichment Analysis Provides Insights into the Heterogeneity of Signaling Pathway Activation in Leukemia Cells
Computational analysis of phosphoproteomics data predicts the sensitivity of leukemia cells to kinase inhibitors.
Perspectives
- Disrupting the Scaffold to Improve Focal Adhesion Kinase–Targeted Cancer Therapeutics
Targeting the scaffold of focal adhesion kinase is a therapeutic opportunity to inhibit signaling pathways selectively in cancer cells.
- A Wnt-er Migration: The Confusing Role of β-Catenin in Melanoma Metastasis
The repertoire of Wnt receptors and co-receptors in melanoma cells may determine whether β-catenin promotes metastasis.
- BIM, PUMA, and the Achilles’ Heel of Oncogene Addiction
Drugs that target oncogenic receptor tyrosine kinases activate parallel signaling pathways that trigger cell death.
Editors' Choice
- Depressed Without Rac1
Treatments that target the GTPase RAC1 signaling could be developed as antidepressants.
- Surface LAT Signals
Early stages of T cell receptor signaling involve recruitment of the plasma membrane–localized adaptor protein LAT into microclusters.
- Protection from Toxic Shock
A glycosphingolipid functions as an endogenous inhibitor of the TLR4-MD2 complex, which mediates the immune response to bacterially derived lipids.
- Dissecting TLR8 Interactions
The crystal structure of unbound and ligand-bound Toll-like receptor 8 reveals ligand-induced conformational changes.
- Interfering with Interferons
Disseminated Mycobacterium leprae infection is associated with blockade of the antimicrobial response by type I interferons.
- Three Tales of Wnt Signaling
New studies elucidate mechanisms of Wnt signaling and implicate spatially restricted Wnt signals in orientation of asymmetric stem cell division.
