Contents

Contents

• Research Article

  • Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death

    By Risheng Xu, Nilkantha Sen, Bindu D. Paul, Adele M. Snowman, Feng Rao, M. Scott Vandiver, Jing Xu, Solomon H. Snyder

    Science Signaling02 Apr 2013 : ra22 Full AccessRestricted Access

    By promoting p53 acetylation and activation, IPMK contributes to DNA damage–induced cell death.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Research Resource

  • The switches.ELM Resource: A Compendium of Conditional Regulatory Interaction Interfaces

    By Kim Van Roey, Holger Dinkel, Robert J. Weatheritt, Toby J. Gibson, Norman E. Davey

    Science Signaling02 Apr 2013 : rs7 Full AccessRestricted Access

    A resource centered on short linear motifs provides a repository and exploratory tool for conditional protein interactions.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • The Scientific Drunk and the Lamppost: Massive Sequencing Efforts in Cancer Discovery and Treatment

    By Michael B. Yaffe

    Science Signaling02 Apr 2013 : pe13 Full AccessRestricted Access

    Signaling networks may provide greater return for the investment in cancer research.

    • Abstract
    • Full Text
    • PDF

• Protocol

  • Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

    By Jianjiong Gao, Bülent Arman Aksoy, Ugur Dogrusoz, Gideon Dresdner, Benjamin Gross, S. Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, Nikolaus Schultz

    Science Signaling02 Apr 2013 : pl1 Full AccessRestricted Access

    The cBioPortal enables integration, visualization, and analysis of multidimensional cancer genomic and clinical data.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 2 April 2013

    By Risheng Xu, Annalisa M. VanHook

    Science Signaling02 Apr 2013 : pc9 Full AccessRestricted Access

    A multifunctional protein promotes acetylation and activation of the tumor suppressor p53.

    • Abstract
    • Full Text

• Editors' Choice

  • Protecting the Heart and Mind from Stress

    By Leslie K. Ferrarelli

    Science Signaling02 Apr 2013 : ec77 Full AccessRestricted Access

    Through independent mechanisms, TLR9 increases stress tolerance in nonimmune cells while initiating inflammation in immune cells after tissue injury.

    • Abstract

  • Remaining Active in Endosomes

    By Wei Wong

    Science Signaling02 Apr 2013 : ec78 Full AccessRestricted Access

    Agonist-bound β₂-adrenergic receptors in endosomes continue to trigger the production of cAMP.

    • Abstract

  • Calling In the Clean-Up Crew

    By Annalisa M. VanHook

    Science Signaling02 Apr 2013 : ec79 Full AccessRestricted Access

    Dying cells release chemotactic cytokines that attract phagocytes.

    • Abstract

  • Making the Final Cut

    By Stella M. Hurtley

    Science Signaling02 Apr 2013 : ec80 Full AccessRestricted Access

    When a daughter cell lets go, the mother cell cuts it loose.

    • Abstract