Contents
Vol 6, Issue 269
Contents
Research Article
- Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death
By promoting p53 acetylation and activation, IPMK contributes to DNA damage–induced cell death.
Research Resource
- The switches.ELM Resource: A Compendium of Conditional Regulatory Interaction Interfaces
A resource centered on short linear motifs provides a repository and exploratory tool for conditional protein interactions.
Perspective
- The Scientific Drunk and the Lamppost: Massive Sequencing Efforts in Cancer Discovery and Treatment
Signaling networks may provide greater return for the investment in cancer research.
Protocol
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
The cBioPortal enables integration, visualization, and analysis of multidimensional cancer genomic and clinical data.
Podcast
- Science Signaling Podcast: 2 April 2013
A multifunctional protein promotes acetylation and activation of the tumor suppressor p53.
Editors' Choice
- Protecting the Heart and Mind from Stress
Through independent mechanisms, TLR9 increases stress tolerance in nonimmune cells while initiating inflammation in immune cells after tissue injury.
- Remaining Active in Endosomes
Agonist-bound β2-adrenergic receptors in endosomes continue to trigger the production of cAMP.
- Calling In the Clean-Up Crew
Dying cells release chemotactic cytokines that attract phagocytes.