Contents
Vol 6, Issue 271
Contents
Research Articles
- Nutrient Signaling in Protein Homeostasis: An Increase in Quantity at the Expense of Quality
Inhibition of mTORC1 by rapamycin may promote longevity by increasing the quality of protein synthesis.
- Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases
Pathological angiogenesis mediated by the VEGF receptor could be treated by combining mTOR and PI3K inhibitors.
Teaching Resources
- p53 as Batman: Using a Movie Plot to Understand Control of the Cell Cycle
Analogies with characters and scenes from a Batman movie illustrate how p53 regulates the cellular response to stress.
- Transport Proteins
Animated lessons describe the classes of transport proteins and illustrate mechanisms of transport.
- Intercellular Transport
Animated lessons illustrate the permeability of four classes of molecules across the plasma membrane and diffusion between cells through gap junctions.
- Coupled Transport Protein Systems
Animated lessons describe gastric pumps, glucose absorption, and CFTR as examples of coupled systems of transport proteins.
- Charged Membranes
Animated lessons describe how Na+- and K+-dependent adenosine triphosphatase (Na+/K+–ATPase) generates an electrochemical gradient across a membrane and provides two examples of how the energy of charged membranes is utilized.
- Using Partial Least Squares Regression to Analyze Cellular Response Data
Multivariate data and context-dependent signaling can be analyzed with the computational approach of PLSR.
Podcast
- Science Signaling Podcast: 16 April 2013
Analysis of VEGF signaling identifies potential therapeutic strategies for treating pathological angiogenesis.
Editors' Choice
- Pressured to Metastasize
Interstitial fluid pressure induces autocrine proliferative and proinvasive glutamate signaling in some cancer cells.
- Heparanase Promotes Exosome Release
The increased abundance of the endoglycosidase heparanase in malignant cells enhances their release of exosomes.
- Pathway of Neurotoxicity
Two hallmarks of Alzheimer’s disease are connected through a CAMKK2-AMPK pathway.
- Transcriptional Reprogramming by TOR
Photosynthesis or glucose stimulates TOR signaling to activate the root meristem.
- Sense and Adapt
The adaptor protein STING may also serve as a sensor in the interferon-mediated response to bacterial infection.
- INTERFER(ON)ing Persistence
Blockade of type I interferons leads to better control of persistent lymphocytic choriomeningitis virus infection.
- Electrical Orienteering
Asymmetric distribution of membrane components may determine asymmetric signaling and directional migration induced by an electric field.
