Contents
Vol 6, Issue 273
Contents
Research Articles
- Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis
Epigenetic changes contribute to a positive feedback loop promoting AP1 activity that contributes to metastasis of squamous cell carcinoma to lymph nodes.
- Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic β Cells
By oscillating between the plasma membrane and the cytosol, Epac2 promotes pulses of insulin secretion.
- β-Arrestin–Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6
Far from being silent, the atypical chemokine receptor D6 depends on β-arrestin signaling to perform its scavenging function to degrade chemokines.
Perspective
- Histone Demethylases Set the Stage for Cancer Metastasis
By modulating metastatic gene expression, histone demethylases are potential targets for suppressing cancer metastasis.
Podcast
- Science Signaling Podcast: 30 April 2013
The chemokine scavenging activity of an atypical chemokine receptor requires signaling through β-arrestin.
Editors' Choice
- Daylight Determines Dopamine
Switching rats from long days to short days causes neurons to change their neurotransmitters, and this changes behavior.
- Where Parkin Parks
The Parkinson’s disease factors PINK1 and Parkin interact with mitofusin 2 on damaged mitochondria.
- Exacerbating Autoimmune Disease with Salt
Sodium chloride promotes the production of pathogenic TH17 cells and exacerbates autoimmune disease.
- Tracking Secreted Proteins
A mass spectrometry–based method detects picogram quantities of proteins secreted by macrophages.
- Reconstituting Angiogenesis in Vitro
An in vitro 3D system enables testing of pro- and anti-angiogenic factors.
- Surviving Glutamine Deprivation
The PP2A subunit B55α triggers the activation of p53 to enable cells to survive glutamine deprivation.
Erratum
