Contents

Contents

• Research Articles

  • Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

    By Shingo Mutoh, Mack Sobhany, Rick Moore, Lalith Perera, Lee Pedersen, Tatsuya Sueyoshi, Masahiko Negishi

    Science Signaling07 May 2013 : ra31 Full AccessRestricted Access

    The epidermal growth factor receptor is an unexpected target of the barbiturate phenobarbital.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53

    By Manabu Kurokawa, Jiyeon Kim, Joseph Geradts, Kenkyo Matsuura, Liu Liu, Xu Ran, Wenle Xia, Thomas J. Ribar, Ricardo Henao, Mark W. Dewhirst, Wun-Jae Kim, Joseph E. Lucas, Shaomeng Wang, Neil L. Spector, Sally Kornbluth

    Science Signaling07 May 2013 : ra32 Full AccessRestricted Access

    Inhibition of the ubiquitin E3 ligase MDM2 in breast cancer cells could overcome lapatinib resistance.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Requirement for Nuclear Calcium Signaling in Drosophila Long-Term Memory

    By Jan-Marek Weislogel, C. Peter Bengtson, Michaela K. Müller, Jan N. Hörtzsch, Martina Bujard, Christoph M. Schuster, Hilmar Bading

    Science Signaling07 May 2013 : ra33 Full AccessRestricted Access

    Blocking nuclear calcium signaling reversibly inhibits long-term memory formation in flies.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • Old Dance with a New Partner: EGF Receptor as the Phenobarbital Receptor Mediating Cyp2B Expression

    By Sharon A. Meyer, Randy L. Jirtle

    Science Signaling07 May 2013 : pe16 Full AccessRestricted Access

    The direct interaction of phenobarbital with the epidermal growth factor receptor reveals a new network interface in nuclear receptor signaling.

    • Abstract
    • Full Text
    • PDF

• Journal Club

  • Decoding the Language of Phosphorylation Site Dynamics

    By Lily A. Chylek

    Science Signaling07 May 2013 : jc2 Full AccessRestricted Access

    Computational modeling sheds light on the interplay of phosphorylation and diffusion in cell signaling.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 7 May 2013

    By Hilmar Bading, Annalisa M. VanHook

    Science Signaling07 May 2013 : pc12 Full AccessRestricted Access

    Calcium signaling is required for long-term memory in fruit flies.

    • Abstract
    • Full Text

• Editors' Choice

  • Making Microbes Multicellular

    By Annalisa M. VanHook

    Science Signaling07 May 2013 : ec101 Full AccessRestricted Access

    Two kinases independently sense reduced respiration to initiate biofilm formation in Bacillus subtilis.

    • Abstract

  • Dissecting Serotonin Receptors

    By L. Bryan Ray

    Science Signaling07 May 2013 : ec102 Full AccessRestricted Access

    Structures of serotonin receptor family members in complex with the fungal alkaloid ergot offer clues for drug designers.

    • Abstract

  • Promoting Single-Cell Invasion

    By Nancy R. Gough

    Science Signaling07 May 2013 : ec103 Full AccessRestricted Access

    EphA2 can promote collective or single-cell invasive phenotypes depending on its cleavage status.

    • Abstract

  • Extrinsic Resistance to Hedgehog Inhibition

    By Leslie K. Ferrarelli

    Science Signaling07 May 2013 : ec104 Full AccessRestricted Access

    The inflammatory cytokine osteopontin stimulates the transcription factor GLI1 to promote multidrug resistance and the epithelial-to-mesenchymal transition.

    • Abstract

• Erratum

  • A Correction to the Perspective Titled: “STIMulating Stress Fibers in Endothelial Cells” by T. Gudermann and D. Steinritz

    Science Signaling07 May 2013 : er2 Full AccessRestricted Access

    An error in the figure of the representation of the TRPC channel is corrected.

    • Full Text
    • PDF