Contents
Vol 6, Issue 274
Contents
Research Articles
- Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling
The epidermal growth factor receptor is an unexpected target of the barbiturate phenobarbital.
- A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53
Inhibition of the ubiquitin E3 ligase MDM2 in breast cancer cells could overcome lapatinib resistance.
- Requirement for Nuclear Calcium Signaling in Drosophila Long-Term Memory
Blocking nuclear calcium signaling reversibly inhibits long-term memory formation in flies.
Perspective
- Old Dance with a New Partner: EGF Receptor as the Phenobarbital Receptor Mediating Cyp2B Expression
The direct interaction of phenobarbital with the epidermal growth factor receptor reveals a new network interface in nuclear receptor signaling.
Journal Club
- Decoding the Language of Phosphorylation Site Dynamics
Computational modeling sheds light on the interplay of phosphorylation and diffusion in cell signaling.
Podcast
- Science Signaling Podcast: 7 May 2013
Calcium signaling is required for long-term memory in fruit flies.
Editors' Choice
- Making Microbes Multicellular
Two kinases independently sense reduced respiration to initiate biofilm formation in Bacillus subtilis.
- Dissecting Serotonin Receptors
Structures of serotonin receptor family members in complex with the fungal alkaloid ergot offer clues for drug designers.
- Promoting Single-Cell Invasion
EphA2 can promote collective or single-cell invasive phenotypes depending on its cleavage status.
- Extrinsic Resistance to Hedgehog Inhibition
The inflammatory cytokine osteopontin stimulates the transcription factor GLI1 to promote multidrug resistance and the epithelial-to-mesenchymal transition.
Erratum
- A Correction to the Perspective Titled: “STIMulating Stress Fibers in Endothelial Cells” by T. Gudermann and D. Steinritz
An error in the figure of the representation of the TRPC channel is corrected.