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Abstract
This Podcast features an interview with Hilmar Bading, senior author of a Research Article that appears in the 7 May 2013 issue of Science Signaling and addresses the requirement for calcium signaling in long-term memory formation in the fruit fly. Short-term memory depends on alterations in the function of existing neuronal connections and is accomplished through changes in the activity, abundance, or distribution of proteins. In contrast, long-term memory depends on structural changes in neuronal connections and requires gene transcription. In vertebrates, these transcriptional changes are mediated by nuclear calcium signaling. Using a Pavlovian conditioning protocol and genetically encoded calcium sensors, Bading's group found that nuclear calcium signaling is also required for long-term memory formation in fruit flies.
