Research ArticleNeuroscience

Requirement for Nuclear Calcium Signaling in Drosophila Long-Term Memory

See allHide authors and affiliations

Science Signaling  07 May 2013:
Vol. 6, Issue 274, pp. ra33
DOI: 10.1126/scisignal.2003598

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Flies Need Nuclear Calcium to Remember

Memory formation is a complex process, and the formation of long-term memories requires changes in gene expression to persistently adapt the neuronal circuitry. The ability to create lasting memories of aversive experiences associated with smells likely provides a survival advantage. Weislogel et al. used fruit flies with genetically encoded calcium sensors and proteins that interfered specifically with the nuclear, but not cytosolic, calcium signals to show in vivo that nuclear calcium was specifically required for changes in long-term olfactory avoidance memory formation, but not for other forms of olfactory avoidance memories that do not require gene expression. This study provides a demonstration of the signals required for lasting memory formation in vivo.