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Elucidating Human Phosphatase-Substrate Networks

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Science Signaling  14 May 2013:
Vol. 6, Issue 275, pp. rs10
DOI: 10.1126/scisignal.2003203

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Investigating the Flip Side of Phosphorylation

Although less studied than their kinase counterparts in the role of phosphorylation in cellular regulation, phosphatases are nevertheless critical players in this dynamic process. Li et al. describe an online resource called DEPOD and the results of their analysis of the human phosphatase-substrate network. The authors present a structure-based classification scheme for the phosphatases that provides insight regarding substrates and enables their prediction. Visualization of the network of substrates and phosphatases reveals multifunctional phosphatases and hub substrates. Mapping of kinase substrates with phosphatase substrates to identify common targets enables predictions of previously unknown phosphatase targets. Thus, this analysis and DEPOD are a useful resource for researchers interested in phosphorylation-mediated regulation.

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