Contents
Vol 6, Issue 276
Contents
Research Articles
- Estrogen Reduces Lipid Content in the Liver Exclusively from Membrane Receptor Signaling
Membrane-localized estrogen receptor can alter metabolism without translocating to the nucleus.
- Eukaryotic G Protein Signaling Evolved to Require G Protein–Coupled Receptors for Activation
As eukaryotic organisms evolved, their Gα proteins switched from being self-activating to requiring an activating receptor.
- Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways
Comparing protein-interaction networks of two species of yeast suggests that network rewiring may enable environmental adaptation.
Perspective
- Understanding the Determinants of Notch Interactions with Its Ligands
Multiple regulatory events govern Notch interactions and response to its ligands.
Review
- Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage
Emerging insight on the structural and functional versatility of Adhesion-GPCRs draws a fascinating picture of the multiple signals these molecules transmit.
Editors' Choice
- Hypoxia Prevents miRNA Processing
Phosphorylation of a microRNA-processing protein by the EGF receptor inhibits maturation of tumor-suppressing microRNAs.
- mTORC1 Stimulates Glutamine Metabolism
The mammalian target of rapamycin complex 1 promotes glutamine metabolism by repressing expression of the gene encoding the sirtuin SIRT4.
- Epigenetic Regulation by Vitamin C
Vitamin C is a cofactor for Tet-mediated DNA demethylation.
- Signal Scaffolds
Scaffolding proteins are active participants in the Wnt and Hippo signaling networks.
- Nuclear Actin in Action
A dynamic polymeric actin structure inside the nucleus is part of the serum response in mammalian tissue culture cells.
- Stress Inside Out
Gram-negative bacteria monitor lipopolysaccharide and outer-membrane protein status to detect and respond to problems.
