Research ArticleEVOLUTION

Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways

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Science Signaling  21 May 2013:
Vol. 6, Issue 276, pp. ra38
DOI: 10.1126/scisignal.2003350

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Network Rewiring

Protein-protein interaction networks represent one important aspect of cellular regulation. Although genomic conservation may indicate that networks should also be conserved, comparison of the stress response signaling networks in two different species of yeast suggests that the networks exhibit substantial rewiring of the interactions. Das et al. compared the interaction networks of proteins, classified as part of the stress response or involved in signal transduction, constructed from yeast two-hybrid data and found that the most orthologous proteins exhibited differences in their interacting partners. This network rewiring may be a mechanism by which different organisms adapt to diverse environments.

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