Contents
Vol 6, Issue 277
Contents
Research Articles
- An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering
Inhibition of adenosine receptors could reduce metastasis by enhancing prenylation-dependent signaling that promotes cell-cell adhesion.
- Tyrosine Kinase BMX Phosphorylates Phosphotyrosine-Primed Motif Mediating the Activation of Multiple Receptor Tyrosine Kinases
The tyrosine kinase BMX targets primed tyrosines in other tyrosine kinases for full activation.
- Automatic Generation of Predictive Dynamic Models Reveals Nuclear Phosphorylation as the Key Msn2 Control Mechanism
Topological filtering identifies biological networks compatible with known data and enables quantitative analysis of regulatory mechanisms.
- Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
A complex that inactivates a GTPase keeps the TORC1 pathway in check in times of amino acid deprivation.
Perspective
- Adenosine Promotes Tumor Metastasis
Adenosine-mediated signaling suppresses the ability of the small GTPase Rap1B to promote cell-cell adhesion.
Podcast
- Science Signaling Podcast: 28 May 2013
The tyrosine kinase BMX may act as a global promoter of maximal receptor tyrosine kinase activity.
Editors' Choice
- Mitochondrial Rb Promotes Apoptosis
The tumor suppressor Rb promotes apoptosis through a transcription-independent mechanism.
- Sugar Aversion
Some German cockroaches find glucose both sweet and bitter, which allows them to avoid baited traps.
- Malaria Cloak and Dagger
A surface protein of Plasmodium falciparum ookinetes allows it to evade the complement-like responses of Anopheles gambiae.
- Obstructing the Craving
A neuroprotective drug may treat cocaine addiction and prevent cocaine-induced neurotoxicity by inhibiting the nitrosylation of GAPDH.
- The Master Switch for Itch?
Natriuretic polypeptide b is the primary neurotransmitter in TRPV1-expressing, itch-sensitive afferent nerve fibers.
- Inflammasome Meets Phagosome
Activation of the NLRP3 inflammasome and caspase 1 are required for the acidification of phagosomes containing Gram-positive bacteria.
- AKAP Functions for Rac1
Rac1 binds to the PKA holoenzyme to enable cAMP-mediated enhancement of the activity of the Rac1 effectors of the PAK family of kinases.
- Sensing Tension
A piconewton tension gauge reveals that less than 12 pN suffices to activate Notch.
- Keeping Coordinated
A protein implicated in oncogenesis is found to be critical for DNA replication in plants and animals.
Erratum
- A Correction to the Research Article Titled: “LEAFY Controls Auxin Response Pathways in Floral Primordium Formation” by W. Li, Y. Zhou, X. Liu, P. Yu, J. D. Cohen, E. M. Meyerowitz
An error in the labeling of panel G in Fig. 2 is corrected.
