An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

Elizabeth Ntantie; Patrick Gonyo; Ellen L. Lorimer; Andrew D. Hauser; Nathan Schuld; Donna McAllister; Balaraman Kalyanaraman; Michael B. Dwinell; John A. Auchampach; Carol L. Williams

doi:10.1126/scisignal.2003374

Research ArticleCell Biology

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

Elizabeth Ntantie¹,
Patrick Gonyo¹,*,
Ellen L. Lorimer¹,*,
Andrew D. Hauser¹,
Nathan Schuld¹,
Donna McAllister²,
Balaraman Kalyanaraman²,
Michael B. Dwinell³,
John A. Auchampach¹, and
Carol L. Williams¹,†

¹Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
²Department of Biophysics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
³Department of Microbiology and Molecular Genetics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

↵†Corresponding author. E-mail: williams{at}mcw.edu

↵* These authors contributed equally to this work.

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Science Signaling 28 May 2013:
Vol. 6, Issue 277, pp. ra39
DOI: 10.1126/scisignal.2003374

Elizabeth Ntantie

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Patrick Gonyo

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Ellen L. Lorimer

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Andrew D. Hauser

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Nathan Schuld

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Donna McAllister

Department of Biophysics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Balaraman Kalyanaraman

Department of Biophysics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Michael B. Dwinell

Department of Microbiology and Molecular Genetics and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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John A. Auchampach

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Carol L. Williams

Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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For correspondence: williams@mcw.edu

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An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

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