Contents
Vol 6, Issue 278
Contents
Research Articles
- TGF-β Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy
Acetylation of chromatin and Ets-1 contributes to induction of miR-192, a microRNA involved in kidney pathogenesis.
- The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling
Inhibition of an inflammatory cytokine signaling pathway by A20 at the receptor may play a role in preventing autoimmunity.
Research Resource
- In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling
Analysis of phosphorylated proteins from the hearts of mice given drugs targeting β-adrenergic receptors may aid in treating heart disease.
Perspective
- Acetylation of Ets-1 Is the Key to Chromatin Remodeling for miR-192 Expression
New insight into epigenetic mechanisms regulating microRNA expression in kidney fibrosis.
Editors' Choice
- Circadian Learning
Transcription-dependent and -independent mechanisms regulated by diurnal glucocorticoid oscillations promote memory formation and retention.
- Repress, Derepress, Activate
Unliganded progesterone receptor recruits a complex that maintains some progesterone-responsive genes in a closed chromatin conformation.
- Defense Without Compromising Development
The identification of JAV1 may enable development of pathogen-resistant plants without compromising development.
- Limiting mTORC1
A protein complex identified as a negative regulator of the mTORC1 protein kinase complex has tumor suppressor functions.
- Phosphorylation-Mediated Knockdown
Phosphorylated chimeric proteins target signaling components for degradation.
