Contents
Vol 6, Issue 281
Contents
Research Articles
- Transient Receptor Potential Channels Function as a Coincidence Signal Detector Mediating Phosphatidylserine Exposure
Platelets use the ion channels TRPC3 and TRPC6 to detect simultaneous exposure to two prothrombotic signals.
- Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells
The guanine nucleotide exchange factor Rapgef2 links cAMP and ERK signaling to mediate neuritogenesis.
Perspective
- A Role for Platelet TRPC Channels in the Ca2+ Response That Induces Procoagulant Activity
Multiple cation channels and an exchanger contribute to calcium signals that stimulate platelet phosphatidylserine exposure.
Editors' Choice
- Pruning Dendrites with Calcium
Localized calcium influx induces developmental dendrite pruning.
- Conserved Signals in Neurodegeneration
Members of the mitogen-activated protein kinase signaling cascade promote the pathogenesis of spinocerebellar ataxia type 1.
- Two Endogenous Modulators in One
The Dbi gene encodes both positive and negative endogenous allosteric regulators of ionotropic GABA receptors.
- Ensuring Effector Function
Rather than using aerobic glycolysis to support their proliferation, activated T cells use this metabolic pathway to produce optimal amounts of interferon-γ.
- GPR15 Gets Tregs to Guard the Gut
A G protein–coupled receptor helps to localize regulatory T cells in the large intestine.
