Research ArticleCell Biology

Transient Receptor Potential Channels Function as a Coincidence Signal Detector Mediating Phosphatidylserine Exposure

See allHide authors and affiliations

Science Signaling  25 Jun 2013:
Vol. 6, Issue 281, pp. ra50
DOI: 10.1126/scisignal.2003701

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Clotting Takes Two Signals

Blood platelets can aggregate to form thrombi to stop blood flow, a necessary physiological process that prevents excessive blood loss but one that can also contribute to blood vessel occlusion and ischemia. Positive feedback loops and integration of multiple signals are mechanisms for regulating biological processes. Harper et al. found that the nonselective cation channels TRPC3 (transient receptor potential C3) and TRPC6 were necessary to enable mouse platelets to expose phosphatidylserine in response to both thrombin and another prothrombotic signal, collagen-related peptide. Sustained calcium influx, which is necessary for phosphatidylserine exposure and thrombin generation, occurred in platelets activated by both thrombin and collagen-related peptide but not in those activated by either signal alone. Understanding how the signaling pathways trigger thrombosis could guide the development of therapies to control blood clotting.