Contents
Vol 6, Issue 283
Contents
Editorial Guide
- Focus Issue: Uncovering the Mechanisms of Neurological Disease
Understanding the molecular mechanisms that cause neurological disease and brain cancer offers the potential of improved therapies.
Research Articles
- Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2
An allosteric inhibitor of the kinase JAK2 impedes the growth of aggressive glioblastoma.
- Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA
Estimation of parameters in a calcium regulatory network from single-cell data illustrates how this approach can reveal protein function.
- JNK3 Couples the Neuronal Stress Response to Inhibition of Secretory Trafficking
Palmitoylated JNK3 sequesters the phosphatase Sac1 at the Golgi to limit trafficking of glutamate receptors to the cell surface.
Perspective
- Presenilins and Calcium Signaling—Systems Biology to the Rescue
New results support function of presenilins as endoplasmic reticulum calcium leak channels.
Review
- Neuroligins Provide Molecular Links Between Syndromic and Nonsyndromic Autism
Targeting synaptic connectivity and plasticity even after development may be possible for treating autism.
Podcast
- Science Signaling Podcast: 9 July 2013
A small-molecule inhibitor of the kinase JAK2 blocks proliferation of glioblastoma cells.
Editors' Choice
- Delivering a Mixed Message
Blood vessel endothelial cells deliver messages triggering both quiescence and proliferation of tumor cells.
- Immunotherapy Packs a One-Two Punch
CD47 antagonists augment the effectiveness of antibody-mediated tumor immunotherapy in mice.
- Enhancer-Targeted Immunosuppression
The Rev-Erb nuclear receptor family represses gene transcription in macrophages indirectly by inhibiting the transcription of enhancer-derived RNAs.
- Autonomous Cycling in a Shared Cytoplasm
Localization of cyclin transcripts enables nuclei sharing a common cytoplasm to divide autonomously.
- Potassium Controls the Inflammasome
The common link among the diverse stimuli that activate the NLRP3 inflammasome is the efflux of intracellular potassium ions.
- RGM Proteins
A complex of a guidance molecule and its receptor reveals how signals cross the membrane.
- Drug Targeting
A method to monitor drug binding to proteins in cells may help in target validation and drug optimization.
