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Abstract
This Podcast features an interview with Keqiang Ye, author of a Research Article that appears in the 9 July 2013 issue of Science Signaling. Glioblastoma is the most common form of aggressive brain cancer, and many glioblastomas contain mutations that cause overactivation of the epidermal growth factor receptor (EGFR), which promotes cell proliferation. In addition to mutations that increase EGFR signaling, some of the most aggressive glioblastomas also have mutations in the gene that encodes PTEN, the phosphatase and tensin homolog, which is a tumor suppressor that inhibits cell proliferation. In a study published in the current issue of Science Signaling, a group led by Keqiang Ye reports their discovery of a small molecule that blocks EGFR activation and inhibits the growth of glioblastoma cells, even when those cells also lack PTEN.
