Contents
Vol 6, Issue 284
Contents
Research Articles
- Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks
Clustering receptor tyrosine kinase networks reveals potentially useful combination cancer therapies to overcome resistance.
- CCAAT/Enhancer Binding Protein δ in Macrophages Contributes to Immunosuppression and Inhibits Phagocytosis in Nasopharyngeal Carcinoma
The transcription factor C/EBPδ makes tumor-associated macrophages produce signals that aid the tumor.
- Release of Nonmuscle Myosin II from the Cytosolic Domain of Tumor Necrosis Factor Receptor 2 Is Required for Target Gene Expression
By binding to tumor necrosis factor receptor 2, myosin limits signaling by TNF-α.
Podcast
- Science Signaling Podcast: 16 July 2013
Proinflammatory signaling by tumor necrosis factor receptor 2 requires that it be released from nonmuscle myosin.
Editors' Choice
- Arginine Methylation Derepresses BMP Signaling
BMP-dependent arginine methylation of the inhibitor Smad6 leads to activation of the effector proteins Smad1 and Smad5.
- Stromal-Induced Survival
Stromal-secreted growth factors induce prosurvival signals mediated by an isoform of p63 in skin cancer.
- Cancer Hits a Nerve
Prostate cancer is more aggressive when certain types of nerves form near and within the tumor.
- Rejecting the Wrong Mate
By touching potential mates, fruit fly males sense the hydrocarbon composition of the female’s cuticle to decide if she is of the right species.
- Confining Hippo for Fate Specification
Polarized distribution of angiomotin restricts Hippo signaling to the inner cell mass in mouse blastocysts.
- Keeping the Inflammasome in Check
Adenosine diphosphate binding to the NOD-like receptor keeps it inactive in the absence of ligands.
- Magnesium to the Rescue
Magnesium supplementation in patients with a primary immunodeficiency restores immune responses to Epstein-Barr virus.
