Science Signaling Podcast: 23 July 2013

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Science Signaling  23 Jul 2013:
Vol. 6, Issue 285, pp. pc19
DOI: 10.1126/scisignal.2004457

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This Podcast features an interview with Daniel Davis, author of a Research Article that appears in the 23 July 2013 issue of Science Signaling. Davis discusses how engagement of an activating receptor triggers reorganization of inhibitory receptors on the surface of natural killer (NK) cells. NK cells are lymphocytes that kill cells that have been infected by viruses or have become cancerous. The activity of NK cells is controlled by the balance between activating and inhibitory signals these cells receive when they encounter a target cell. Whereas activating signals promote killing of the target cell, inhibitory signals spare the cell. In a study published in the current issue of Science Signaling, Pageon et al. use superresolution microscopy to demonstrate that the spatial arrangement of the inhibitory receptor KIR2DL1 on the NK cell surface changes upon engagement of the activating receptor NKG2D.

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