Contents
Vol 6, Issue 287
Contents
Research Articles
- The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells
Amplification of downstream signaling by AXL receptor tyrosine kinase alters the migratory response of breast cancer cells.
- Interference with Akt Signaling Protects Against Myocardial Infarction and Death by Limiting the Consequences of Oxidative Stress
Reducing Akt activity might alleviate cardiovascular complications and mortality associated with atherosclerosis.
Research Resource
- Simultaneous Profiling of 194 Distinct Receptor Transcripts in Human Cells
Receptor transcript profiling defines context-specific signaling signatures.
Podcast
- Science Signaling Podcast: 6 August 2013
Amplification of the receptor tyrosine kinase AXL correlates with resistance to ErbB inhibitors in cancer cells.
Editors' Choice
- Painful Long Noncoding RNA
Peripheral nerve injury induces an lncRNA that reduces the abundance of a potassium channel, thereby increasing neuronal excitability.
- Yap Methylated
The methyltransferase Set7 promotes cytoplasmic retention of the transcriptional coactivator Yap.
- Simple Signals?
Information theory analysis of cell signaling reveals mechanisms for reliable cellular responses despite signal variability.
- As the Worm Squirms
A worm model of ischemia-reperfusion injury reveals protective mechanisms potentially relevant to stroke and heart attack.
- Protecting the Guts
Bacterial fermentation products regulate the number and function of regulatory T cells in the mouse colon.
- Bacterial Subversion Tactics
The bacterial pathogen Listeria monocytogenes exploits histone modifications to reprogram its host.
- Modification Without Enzymes
A reactive intermediate formed during glycolysis reacts nonenzymatically to inhibit glycolytic enzymes.
