Research ArticleCancer The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells Aaron S. Meyer1,2, Miles A. Miller1, Frank B. Gertler2,3, and Douglas A. Lauffenburger1,2,3,*1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.↵*Corresponding author. E-mail: lauffen{at}mit.edu See allHide authors and affiliations Science Signaling 06 Aug 2013:Vol. 6, Issue 287, pp. ra66DOI: 10.1126/scisignal.2004155 Aaron S. Meyer 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Miles A. Miller 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Frank B. Gertler 2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Douglas A. Lauffenburger 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: lauffen@mit.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 6 no. 287 ra66 DOI: https://doi.org/10.1126/scisignal.2004155 PubMed: 23921085 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received March 15, 2013Accepted July 15, 2013 . Copyright & Usage: Copyright © 2013, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2013 to February 2021 AbstractFullPdf Aug 20133414355853 Sep 2013856216301 Oct 2013598105193 Nov 201339966130 Dec 20133243677 Jan 20142133177 Feb 20141954456 Mar 20141382541 Apr 20141061526 May 20141211527 Jun 20141141428 Jul 20141222319 Aug 20143092937 Sep 20141104242 Oct 2014794636 Nov 2014683431 Dec 2014592724 Jan 2015894626 Feb 20152834434 Mar 2015673131 Apr 2015874837 May 2015863226 Jun 2015893129 Jul 2015611432 Aug 201501523 Sep 201522914 Oct 201582016 Nov 201521426 Dec 201541526 Jan 201686713 Feb 2016831231 Mar 20161281020 Apr 201675820 May 201666514 Jun 20161691121 Jul 201695614 Aug 201699317 Sep 2016971118 Oct 20161801142 Nov 20161791143 Dec 20161951118 Jan 201711287 Feb 201786820 Mar 20171202119 Apr 2017921121 May 2017102615 Jun 2017187812 Jul 2017132422 Aug 201716533 Sep 20177855 Oct 201770415 Nov 20179056 Dec 20175528 Jan 20186557 Feb 2018100812 Mar 20181312014 Apr 20181031116 May 20181621726 Jun 201881127 Jul 20186877 Aug 2018457015 Sep 2018413416 Oct 2018646012 Nov 20181316817 Dec 2018835923 Jan 201971178 Feb 201957213 Mar 2019622813 Apr 2019356117 May 2019402414 Jun 2019332911 Jul 2019473919 Aug 201929243 Sep 201935289 Oct 2019533221 Nov 2019804530 Dec 2019962924 Jan 202034658 Feb 202025114 Mar 202056139 Apr 20202992 May 202030407 Jun 2020781510 Jul 20202443 Aug 202017126 Sep 202023117 Oct 202059198 Nov 2020462116 Dec 2020354330 Jan 2021201611 Feb 20212774 View Full Text
The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells By Aaron S. Meyer, Miles A. Miller, Frank B. Gertler, Douglas A. Lauffenburger Science Signaling06 Aug 2013 : ra66 Amplification of downstream signaling by AXL receptor tyrosine kinase alters the migratory response of breast cancer cells. Supplementary Materials
The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells By Aaron S. Meyer, Miles A. Miller, Frank B. Gertler, Douglas A. Lauffenburger Science Signaling06 Aug 2013 : ra66 Amplification of downstream signaling by AXL receptor tyrosine kinase alters the migratory response of breast cancer cells. Supplementary Materials