PerspectiveReproductive Biology

Resolving Molecular Events in the Regulation of Meiosis in Male and Female Germ Cells

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Science Signaling  13 Aug 2013:
Vol. 6, Issue 288, pp. pe25
DOI: 10.1126/scisignal.2004530


  • Fig. 1 Proposed model for sex-specific control of meiotic induction based on genetic findings.

    RA generated in the mesonephros acts locally to control differentiation of Müllerian (md) and Wolffian (wd) ducts (12), but diffusion of mesonephric RA to prenatal ovary or prenatal testis is insufficient to induce meiosis in prenatal PGCs that lack enzymes to locally generate RA (6). By contrast, RA is generated locally in PGCs of postnatal testis and is required to induce Stra8 for male meiotic induction (11); RA produced in postnatal male PGCs may directly or indirectly release PRC1 repression to induce Stra8. M, mesonephros; Ov, ovary; Tes, testis.


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