Contents
Vol 6, Issue 289
Contents
Research Articles
- Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses
Loss-of-function analyses in yeast and flies identify molecular complexes that regulate ribosomal DNA transcription.
- The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3
The kinase Syk maintains a balanced immune response to pathogens detected by the receptor TLR4.
- A Physical Interaction Between the Adaptor Proteins DOK3 and DAP12 Is Required to Inhibit Lipopolysaccharide Signaling in Macrophages
The association of two immune adaptor proteins dampens inflammatory responses to a bacterial product.
Review
- Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis
More investigation into the role of lncRNAs in blood cell development and blood cell cancers is warranted.
Editors' Choice
- Repairing the Heart
An inflammatory response pathway mediates heart muscle regeneration in zebrafish.
- Food as Reward
In mice, a high-fat diet functionally disrupts a gut lipid that controls the brain’s perception of the reward value of food.
- Gαi-GDP Points the Way
The GDP-bound form of a G protein α subunit recruits a polarity complex important for neutrophil migration.
- Turning On the Repulsive System
Sonic hedgehog uses glypican1 to trigger the expression of the gene encoding its co-receptor Hhip to switch the response from attraction to repulsion.
- Allergy Induction
Allergic inflammation requires proteinase-dependent cleavage of fibrinogen that activates innate immunity through Toll-like receptor 4.
- A New Linc in Innate Immunity
In mice, a broadly acting RNA, lincRNA-Cox2, regulates the circuit that controls the inflammatory response.
- How to Stop Responding to Stressful Conditions
Astrin prevents the association of mTOR and raptor to limit mTORC1 activation in response to stress.
