Contents
Vol 6, Issue 292
Contents
Research Articles
- The Scaffold Protein Prohibitin Is Required for Antigen-Stimulated Signaling in Mast Cells
Targeting a scaffold protein delivered by intracellular granules in mast cells may inhibit allergic responses.
- Ajuba Family Proteins Link JNK to Hippo Signaling
An evolutionarily conserved family of proteins links pathways to promote cell proliferation in response to cell death or injury.
Perspective
- A Role for Prohibitin in Mast Cell Activation: Location Matters
The protein prohibitin mediates receptor-proximal events to stimulate antigen-dependent degranulation of mast cells.
Podcast
- Science Signaling Podcast: 10 September 2013
An adaptor protein promotes nuclear accumulation of the transcriptional coactivator Yorkie in response to JNK signaling.
Editors' Choice
- Painful Subversion of the Host Defense
Bacteria have two mechanisms for directly activating pain-sensing (nociceptive) neurons.
- Always at Your Beclin Call
Beclin 2 coordinates autophagy and degradation of G protein–coupled receptors.
- Resetting a Lagging Body Clock
Inhibiting a kinase activated in response to light may accelerate the body’s adjustment to circadian rhythm disruptions.
- PTTH Induces Photophobia
A single neuropeptide controls both wandering and light avoidance behaviors in fruit fly larvae.
- Deafness and Misbehavior
In mutant mice, severe ear dysfunction is associated with motor hyperactivity.
- From Moles to Melanoma
Genetic variants of the melanocortin-1 receptor fail to protect PTEN from destruction, enabling excessive proliferative and survival signaling.
Erratum
- A Correction to the Research Article Titled: “miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR” by M. Yaseen Balkhi, O. H. Iwenofu, N. Bakkar, K. J. Ladner, D. S. Chandler, P. J. Houghton, C. A. London, W. Kraybill, D. Perrotti, C. M. Croce, C. Keller, D. C. Guttridge
A correction to the first author's name is made.
