Contents
Vol 6, Issue 293
Contents
Research Articles
- A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif
A cancer-associated mutation in protein kinase Cι selectively disrupts epithelial polarity by inhibiting the binding of specific substrates.
- The Transcription Factor CREB Enhances Interleukin-17A Production and Inflammation in a Mouse Model of Atherosclerosis
A lipoxygenase exacerbates atherosclerosis in mice by stimulating macrophages to produce a proinflammatory cytokine.
Perspective
- Brd4 Shields Chromatin from ATM Kinase Signaling Storms
New studies identify chromatin-binding proteins that modulate ATM signaling in response to DNA damage.
Podcast
- Science Signaling Podcast: 17 September 2013
A cancer-associated mutation in PKCι maps to a motif that mediates interactions between PKCι and substrates involved in cell polarity.
Editors' Choice
- Presenilin Lets the Ca2+ Out of the Bag
Presenilins promote synaptic potentiation by stabilizing ryanodine receptors.
- Move Over, TLR4
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
- Arginine GlcNAcylation for Infection
Bacteria modify death domain proteins with GlcNAcylation to compromise apoptotic and inflammatory responses.
- High-Temperature Mating Success
A peptide produced in pistils promotes pollen performance and mitochondrial activity at high temperature.
- Cutting Off EMT at the Pass
Critical signal transduction components in the epithelial-to-mesenchymal transition of breast and brain cancer offer new clinical targets.
