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Abstract
This Podcast features an interview with Peter Parker, Mark Linch, and Neil McDonald, authors of a Research Article that appears in the 17 September 2013 issue of Science Signaling. Atypical protein kinase Cι (PKCι) is a serine-threonine kinase that affects many cellular processes, including apical-basal polarity in epithelial cells. Loss of cell polarity is associated with aggressive epithelial cell cancers, and PKCι is frequently found in abnormally high abundance in epithelial cancers. Linch et al. identified a motif within PKCι that mediates interactions between PKCι and some of its substrates that control cell polarity. They also found that an amino acid within this motif is commonly affected in PKCι mutants associated with human cancer.
