A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

Mark Linch; Marta Sanz-Garcia; Erika Soriano; Yixiao Zhang; Philippe Riou; Carine Rosse; Angus Cameron; Phillip Knowles; Andrew Purkiss; Svend Kjaer; Neil Q. McDonald; Peter J. Parker

doi:10.1126/scisignal.2004068

Research ArticleCell Biology

A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

Mark Linch¹,²,*,
Marta Sanz-Garcia¹,*,
Erika Soriano³,
Yixiao Zhang¹,
Philippe Riou¹,
Carine Rosse¹,
Angus Cameron¹,
Phillip Knowles³,
Andrew Purkiss³,
Svend Kjaer³,
Neil Q. McDonald³,⁴,†, and
Peter J. Parker¹,⁵,†

¹Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.
²Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
³Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.
⁴Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.
⁵Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 1UL, UK.

↵†Corresponding author. E-mail: peter.parker{at}cancer.org.uk (P.J.P.); neil.mcdonald{at}cancer.org.uk (N.Q.M.)

↵* These authors contributed equally to this work.

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Science Signaling 17 Sep 2013:
Vol. 6, Issue 293, pp. ra82
DOI: 10.1126/scisignal.2004068

Mark Linch

Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

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Marta Sanz-Garcia