A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

Mark Linch; Marta Sanz-Garcia; Erika Soriano; Yixiao Zhang; Philippe Riou; Carine Rosse; Angus Cameron; Phillip Knowles; Andrew Purkiss; Svend Kjaer; Neil Q. McDonald; Peter J. Parker

doi:10.1126/scisignal.2004068

Research ArticleCell Biology

A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

Mark Linch¹,²,*,
Marta Sanz-Garcia¹,*,
Erika Soriano³,
Yixiao Zhang¹,
Philippe Riou¹,
Carine Rosse¹,
Angus Cameron¹,
Phillip Knowles³,
Andrew Purkiss³,
Svend Kjaer³,
Neil Q. McDonald³,⁴,†, and
Peter J. Parker¹,⁵,†

¹Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.
²Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
³Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.
⁴Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.
⁵Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 1UL, UK.

↵†Corresponding author. E-mail: peter.parker{at}cancer.org.uk (P.J.P.); neil.mcdonald{at}cancer.org.uk (N.Q.M.)

↵* These authors contributed equally to this work.

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Science Signaling 17 Sep 2013:
Vol. 6, Issue 293, pp. ra82
DOI: 10.1126/scisignal.2004068

Mark Linch

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

2Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

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Marta Sanz-Garcia

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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Erika Soriano

3Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.

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Yixiao Zhang

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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Philippe Riou

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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Carine Rosse

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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Angus Cameron

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

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Phillip Knowles

3Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.

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Andrew Purkiss

3Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.

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Svend Kjaer

3Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.

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Neil Q. McDonald

3Structural Biology Laboratory, Cancer Research UK, London WC2A 3LY, UK.

4Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.

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For correspondence: peter.parker@cancer.org.uk neil.mcdonald@cancer.org.uk

Peter J. Parker

1Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

5Division of Cancer Studies, King’s College London, Guy’s Hospital, London SE1 1UL, UK.

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For correspondence: peter.parker@cancer.org.uk neil.mcdonald@cancer.org.uk

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A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

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