Contents
Vol 6, Issue 294
Contents
Editorial Guide
- Focus Issue: Networking Cancer Treatment Strategies
Using network-level activity markers in cancer cells to predict sensitivity to kinase inhibitors may improve treatment strategy and clinical efficacy.
Research Articles
- Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines
Activity of receptor tyrosine kinase networks may serve as an effective means to classify breast cancers and predict their sensitivity to therapeutic drugs.
- Drug Synergy Screen and Network Modeling in Dedifferentiated Liposarcoma Identifies CDK4 and IGF1R as Synergistic Drug Targets
Drug screening and computational modeling of oncogenic signaling pathways identifies synergistic drug pairs for liposarcoma.
Perspectives
- mTORC1 Status Dictates Tumor Response to Targeted Therapeutics
Recent studies indicate that sustained mTORC1 signaling can cause resistance to pathway-specific kinase inhibitors in cancer.
- What Lies Beneath: Looking Beyond Tumor Genetics Shows the Complexity of Signaling Networks Underlying Drug Sensitivity
Two studies show the power of systems biology methods to improve cancer drug development and treatment strategy.
Review
- Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer
The mechanisms mediating kinase inhibitor resistance in lung cancer are reviewed.
Podcast
- Science Signaling Podcast: 24 September 2013
Drug screening and network modeling suggest a combination therapy for liposarcoma.
Editors' Choice
- Combining Anti-Inflammatory and Anti-Angiogenic Therapy
Targeting the cytokine IL-17 could attenuate the resistance that tumors develop to therapies that block angiogenesis.
- Promoting Metastasis with Ubiquitin
A ubiquitin ligase enhances TGF-β receptor signaling to promote metastasis of breast cancer.
- Inhibiting Autophagy by Phosphorylation
Receptor tyrosine kinase inhibitors alleviate inhibition of autophagy to promote toxicity.
- Demethylation Needed to Forget
Epigenetic changes to DNA are necessary in mice for memory extinction.
- Toward Synthetic Biology
A synthetic control module inserted into yeast cells allows control of cell fate in response to an environmental signal.
- Pain and Dependence
Transient inflammation can lead to prolonged activation of pain-relieving opioid receptors in the spinal cord.
- Amyloid Binding Partners
A potential β-amyloid receptor in neurons regulates ocular dominance in mouse brain development.
- CCR5-Maraviroc Structure
The crystal structure of the HIV co-receptor CCR5 bound to the HIV drug maraviroc provides insight into how HIV enters cells.
- Alarm Bells
The cytosolic DNA sensor cyclic guanosine monophosphate–adenosine monophosphate synthase is essential for antiviral immunity in vivo.
- Stealth Nod Factor Recognition
Nitrogen-fixing bacteria dampen immune responses in their plant hosts.
