Contents

Contents

• Research Articles

  • Depletion of the 26S Proteasome Adaptor Ecm29 Increases Toll-Like Receptor 3 Signaling

    By Carlos Gorbea, Martin Rechsteiner, Jesús G. Vallejo, Neil E. Bowles

    Science Signaling01 Oct 2013 : ra86 Full AccessRestricted Access

    Responses to viral infection involve both proteasomal and autophagy-mediated degradation events.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

    By Jianhui Ma, Bo-Ram Bang, Jiawei Lu, So-Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang

    Science Signaling01 Oct 2013 : ra87 Full AccessRestricted Access

    Limiting the late phase of the macrophage response to microbial products can prevent lethal sepsis in mice.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 1 October 2013

    By Carlos Gorbea, Annalisa M. VanHook

    Science Signaling01 Oct 2013 : pc26 Full AccessRestricted Access

    A subset of 26S proteasomes attenuates TLR3-mediated antiviral signaling.

    • Abstract
    • Full Text

• Editors' Choice

  • Strong Bones for a Strong Mind

    By Annalisa M. VanHook

    Science Signaling01 Oct 2013 : ec234 Full AccessRestricted Access

    A hormone secreted by osteoblasts protects mice from depression and anxiety and promotes learning.

    • Abstract

  • Cycling to Live Differently

    By Jason D. Berndt

    Science Signaling01 Oct 2013 : ec235 Full AccessRestricted Access

    The cell cycle determines the cell fate of embryonic stem cells.

    • Abstract

  • Dictating the Route

    By Nancy R. Gough

    Science Signaling01 Oct 2013 : ec236 Full AccessRestricted Access

    Phosphorylation of a specific tyrosine residue on the receptor controls whether a fibroblast growth factor receptor is recycled or degraded.

    • Abstract

  • Antiviral Skin Helpers

    By Leslie K. Ferrarelli

    Science Signaling01 Oct 2013 : ec237 Full AccessRestricted Access

    Secretion of a cytokine by T helper cells protects psoriatic lesions from viral infection.

    • Abstract

  • Diurnal Immunology

    By Kristen L. Mueller

    Science Signaling01 Oct 2013 : ec238 Full AccessRestricted Access

    The clock protein Bmal1 regulates daily changes in white blood cell trafficking and susceptibility to inflammation in mice.

    • Abstract

  • Drugs, Dopamine, and Disinhibition

    By Peter R. Stern

    Science Signaling01 Oct 2013 : ec239 Full AccessRestricted Access

    Changes in specific neuronal circuits suggest that drug-evoked synaptic plasticity facilitates drug-adaptive behavior.

    • Abstract