Contents
Vol 6, Issue 295
Contents
Research Articles
- Depletion of the 26S Proteasome Adaptor Ecm29 Increases Toll-Like Receptor 3 Signaling
Responses to viral infection involve both proteasomal and autophagy-mediated degradation events.
- The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation
Limiting the late phase of the macrophage response to microbial products can prevent lethal sepsis in mice.
Podcast
- Science Signaling Podcast: 1 October 2013
A subset of 26S proteasomes attenuates TLR3-mediated antiviral signaling.
Editors' Choice
- Strong Bones for a Strong Mind
A hormone secreted by osteoblasts protects mice from depression and anxiety and promotes learning.
- Cycling to Live Differently
The cell cycle determines the cell fate of embryonic stem cells.
- Dictating the Route
Phosphorylation of a specific tyrosine residue on the receptor controls whether a fibroblast growth factor receptor is recycled or degraded.
- Antiviral Skin Helpers
Secretion of a cytokine by T helper cells protects psoriatic lesions from viral infection.
- Diurnal Immunology
The clock protein Bmal1 regulates daily changes in white blood cell trafficking and susceptibility to inflammation in mice.
- Drugs, Dopamine, and Disinhibition
Changes in specific neuronal circuits suggest that drug-evoked synaptic plasticity facilitates drug-adaptive behavior.