01 October 2013
Vol 6, Issue 295

About The Cover

Cover image expansion

Online Cover This week features a Research Article that suggests that the proteasomal adaptor protein Ecm29 acts as an inhibitor of Toll-like receptor 3 (TLR3) signaling by stimulating the autophagic degradation of TLR3 and some of its downstream effectors. The image shows the staining of HeLa cells for TLR3 (red) and Ecm29 (green) that accumulate around nuclei (white) in response to a TLR3 agonist. [Image: Carlos Gorbea and Neil Bowles, Division of Cardiology, University of Utah School of Medicine]