Research ArticleImmunology
The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation
- Jianhui Ma1,*,
- Bo-Ram Bang1,*,
- Jiawei Lu1,2,
- So-Young Eun3,
- Motoyuki Otsuka4,
- Michael Croft3,
- Peter Tobias1,
- Jiahuai Han2,
- Osamu Takeuchi5,
- Shizuo Akira6,
- Michael Karin7,
- Hideo Yagita8, and
- Young Jun Kang1,*,†
- 1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
- 2State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
- 3Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
- 4Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
- 5Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
- 6Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
- 7Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
- 8Department of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
- ↵†Corresponding author. E-mail: ykang{at}scripps.edu
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Science Signaling 01 Oct 2013:
Vol. 6, Issue 295, pp. ra87
DOI: 10.1126/scisignal.2004431
