The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

Jianhui Ma; Bo-Ram Bang; Jiawei Lu; So-Young Eun; Motoyuki Otsuka; Michael Croft; Peter Tobias; Jiahuai Han; Osamu Takeuchi; Shizuo Akira; Michael Karin; Hideo Yagita; Young Jun Kang

doi:10.1126/scisignal.2004431

Research ArticleImmunology

The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

Jianhui Ma¹,*,
Bo-Ram Bang¹,*,
Jiawei Lu¹,²,
So-Young Eun³,
Motoyuki Otsuka⁴,
Michael Croft³,
Peter Tobias¹,
Jiahuai Han²,
Osamu Takeuchi⁵,
Shizuo Akira⁶,
Michael Karin⁷,
Hideo Yagita⁸, and
Young Jun Kang¹,*,†

¹Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
²State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
³Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
⁴Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
⁵Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
⁶Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
⁷Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
⁸Department of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.

↵†Corresponding author. E-mail: ykang{at}scripps.edu

↵* These authors contributed equally to this work.

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Science Signaling 01 Oct 2013:
Vol. 6, Issue 295, pp. ra87
DOI: 10.1126/scisignal.2004431

Jianhui Ma

1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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Bo-Ram Bang

1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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Jiawei Lu

1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

2State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.

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So-Young Eun

3Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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Motoyuki Otsuka

4Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

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Michael Croft

3Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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Peter Tobias

1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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Jiahuai Han

2State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.

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Osamu Takeuchi

5Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

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Shizuo Akira

6Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

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Michael Karin

7Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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Hideo Yagita

8Department of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.

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Young Jun Kang

1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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For correspondence: ykang@scripps.edu

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The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

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