Contents
Vol 6, Issue 296
Contents
Research Articles
- Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells
Fat-overloaded hepatocytes release microparticles that induce angiogenesis and worsening of fatty liver disease.
- Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function
Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.
Review
- Hippo Gains Weight: Added Insights and Complexity to Pathway Control
Multiple regulatory inputs govern Hippo pathway activity and tissue growth.
Podcast
- Science Signaling Podcast: 8 October 2013
Microparticles released by fat-laden hepatocytes stimulate angiogenesis and contribute to the progression of fatty liver disease.
Editors' Choice
- The Inflammasome and Transplantation
The NLRP3 inflammasome is activated during the preconditioning phase of transplantation and mediates graft-versus-host disease in mice.
- Tricellular Cooperation
Three cells communicate to maintain vessel integrity as lymphocytes pass into the lymph nodes.
- Ephrin-A2 Un-Glu’s the Synapse
Ephrin-A2 increases glutamate reuptake transporter abundance to control synaptic glutamate concentrations and prevent synapse elimination.
- A Salty Switch
Synaptic and nonsynaptic signaling contribute to the worm response to high-salt stimuli.
- Pacing Acidification for Neural Development
Premature acidification of endosomes attenuates neurotrophin signaling and hampers axonal and dendrite branching.
- Resetting the Circadian Clock
In mice, the pace of recovery from jet lag is partly determined by vasopressin signaling in a certain region of the brain.
- RNA on the Attack
A pathogenic fungus delivers small RNA molecules to disable gene regulatory systems in the target plant.
