22 October 2013
Vol 6, Issue 298

About The Cover

Cover image expansion

Online Cover This week features a Research Article that identifies the binding site on Epac2A for antidiabetic drugs known as sulfonylureas. Knowing the amino acids that mediate this binding may enable the development of improved therapies. The image shows the structure of a sulfonylurea glibenclamide (space fill) bound to a cyclic nucleotide binding domain of Epac2A (ribbon). [Image: Chris Bickel/AAAS]