Contents
Vol 6, Issue 298
Contents
Research Articles
- Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist
Activation of GPR17 prevents oligodendrocyte maturation and reveals that inhibiting GPR17 may be a therapeutic strategy to treat multiple sclerosis.
- Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A
Identification of the binding site of Epac2A for an antidiabetic drug may enable the development of improved therapies.
Perspective
- Enigmatic GPCR Finds a Stimulating Drug
A small-molecule agonist provides insight into the function and therapeutic potential of the receptor GPR17.
Editors' Choice
- How HIV Reduces Antifungal Immunity
The receptor NKp30 mediates fungal recognition by natural killer (NK) cells and is reduced in NK cells from HIV patients.
- Tears Signal Immaturity
Juvenile mice secrete a signal in their tears that prevents inappropriate mating by adult males.
- Olfactory Neurons Get Stressed Out
Olfactory receptors self-select by inducing the unfolded protein response.
- Return of the Steroid
Phototransformation of growth steroid metabolites is readily reversible in aquatic environments.
- Deciphering the Signatures of Bone Metastases
Bone-metastasized breast cancer cells secrete a protein that alters the regulatory microRNA network, promoting the formation of destructive osteoclasts.
