Contents

Contents

• Research Articles

  • Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist

    By Stephanie Hennen, Haibo Wang, Lucas Peters, Nicole Merten, Katharina Simon, Andreas Spinrath, Stefanie Blättermann, Rhalid Akkari, Ramona Schrage, Ralf Schröder, Daniel Schulz, Celine Vermeiren, Katrin Zimmermann, Stefan Kehraus, Christel Drewke, Alexander Pfeifer, Gabriele M. König, Klaus Mohr, Michel Gillard, Christa E. Müller, Q. Richard Lu, Jesus Gomeza, Evi Kostenis

    Science Signaling22 Oct 2013 : ra93 Full AccessRestricted Access

    Activation of GPR17 prevents oligodendrocyte maturation and reveals that inhibiting GPR17 may be a therapeutic strategy to treat multiple sclerosis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A

    By Toshimasa Takahashi, Tadao Shibasaki, Harumi Takahashi, Kenji Sugawara, Aika Ono, Naoko Inoue, Toshio Furuya, Susumu Seino

    Science Signaling22 Oct 2013 : ra94 Full AccessRestricted Access

    Identification of the binding site of Epac2A for an antidiabetic drug may enable the development of improved therapies.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • Enigmatic GPCR Finds a Stimulating Drug

    By T. Kendall Harden

    Science Signaling22 Oct 2013 : pe34 Full AccessRestricted Access

    A small-molecule agonist provides insight into the function and therapeutic potential of the receptor GPR17.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • How HIV Reduces Antifungal Immunity

    By Annalisa M. VanHook

    Science Signaling22 Oct 2013 : ec253 Full AccessRestricted Access

    The receptor NKp30 mediates fungal recognition by natural killer (NK) cells and is reduced in NK cells from HIV patients.

    • Abstract

  • Tears Signal Immaturity

    By Nancy R. Gough

    Science Signaling22 Oct 2013 : ec254 Full AccessRestricted Access

    Juvenile mice secrete a signal in their tears that prevents inappropriate mating by adult males.

    • Abstract

  • Olfactory Neurons Get Stressed Out

    By Jason D. Berndt

    Science Signaling22 Oct 2013 : ec255 Full AccessRestricted Access

    Olfactory receptors self-select by inducing the unfolded protein response.

    • Abstract

  • Return of the Steroid

    By Nicholas S. Wigginton

    Science Signaling22 Oct 2013 : ec256 Full AccessRestricted Access

    Phototransformation of growth steroid metabolites is readily reversible in aquatic environments.

    • Abstract

  • Deciphering the Signatures of Bone Metastases

    By Leslie K. Ferrarelli

    Science Signaling22 Oct 2013 : ec257 Full AccessRestricted Access

    Bone-metastasized breast cancer cells secrete a protein that alters the regulatory microRNA network, promoting the formation of destructive osteoclasts.

    • Abstract