22 October 2013
Vol 6, Issue 298
  • Contents

    • Research Articles

    • Perspective

    • Editors' Choice

      • How HIV Reduces Antifungal Immunity

        The receptor NKp30 mediates fungal recognition by natural killer (NK) cells and is reduced in NK cells from HIV patients.

      • Tears Signal Immaturity

        Juvenile mice secrete a signal in their tears that prevents inappropriate mating by adult males.

      • Return of the Steroid

        Phototransformation of growth steroid metabolites is readily reversible in aquatic environments.

      • Deciphering the Signatures of Bone Metastases

        Bone-metastasized breast cancer cells secrete a protein that alters the regulatory microRNA network, promoting the formation of destructive osteoclasts.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that identifies the binding site on Epac2A for antidiabetic drugs known as sulfonylureas. Knowing the amino acids that mediate this binding may enable the development of improved therapies. The image shows the structure of a sulfonylurea glibenclamide (space fill) bound to a cyclic nucleotide binding domain of Epac2A (ribbon). [Image: Chris Bickel/AAAS]