Contents
Vol 6, Issue 299
Contents
Research Article
- Convergence of G Protein–Coupled Receptor and S-Nitrosylation Signaling Determines the Outcome to Cardiac Ischemic Injury
S-nitrosothiols protect against ischemic injury in the heart by limiting signaling downstream of G protein–coupled receptors.
Research Resource
- Distinct Signaling Roles of Ceramide Species in Yeast Revealed Through Systematic Perturbation and Systems Biology Analyses
Distinct transcriptional modules are regulated by specific ceramides.
Podcast
- Science Signaling Podcast: 29 October 2013
Cardioprotection by S-nitrosothiols is mediated by inhibition of G protein–coupled receptor kinase 2.
Editors' Choice
- Fatty Rhythms
Circadian secretion of a lipid metabolite from the liver induces fatty acid uptake in the muscle.
- Buying Time with miRNAs
The activity of microRNAs affects the periodicity of the mammalian circadian clock.
- Better Metabolism Through Oxygen Deprivation
Targeting the components of a hypoxia signaling pathway in liver could be a strategy to treat diabetes.
- Plants Sense a Blue Light Special
Plant photoreceptors cooperate to regulate transcription in response to blue light.
- EGFR and IL-6R Cooperate
The epidermal growth factor receptor sustains signaling by the cytokine interleukin-6.
- Guardian of the Gut
Mucus not only forms a physical barrier in the intestine but also promotes immunological tolerance of bacteria and foods.
- Connecting Energy Status to Proliferation
By phosphorylating the kinase B-Raf, the energy-responsive kinase AMPK inhibits signals that lead to cell proliferation.
