Contents
Vol 6, Issue 300
Contents
Research Articles
- Antagonistic Feedback Loops Involving Rau and Sprouty in the Drosophila Eye Control Neuronal and Glial Differentiation
Balanced feedback loops in a receptor tyrosine kinase network control glial and neuronal differentiation in the fly eye.
- The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity
The duration of T cell receptor contact with antigen modulates the pattern of downstream signaling to determine CD4+ T cell fate.
Perspective
- Opposing Feedbacks on Ras Tune Receptor Tyrosine Kinase Signaling
The identification of Rau reveals how signaling activity that directs neuronal and glial fate is maintained in the Drosophila eye.
Podcast
- Science Signaling Podcast: 5 November 2013
The duration of T cell receptor signaling plays a crucial role in the specification of helper and regulatory T cells.
Editors' Choice
- Long Life Through Damaged Mitochondria
Mild mitochondrial dysfunction activates pathways that promote longevity.
- Micromanaging Cancer
In lymphoma, an oncogenic microRNA outcompetes a tumor-suppressive microRNA encoded by the same gene.
- No Migration Without Sequestration
Migratory zebrafish cells create their own chemoattractant gradient.
- Wiring the Retina
Work in mice reveals how motion-detection circuitry is established during visual system development.
- Dinner Time!
The coenzyme nicotinamide adenine dinucleotide mechanistically links the circadian clock to control of energy production by mitochondria.
- First Defense
The molecular basis for how a plant heterodimeric receptor responds to bacterial infection signals is elucidated.
- Chilly Repression Stalls Flowering
A warm spring favors early flowering by invoking less transcriptional repression by a floral repressor complex.
